Details der Publikation - The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery

The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery

Purposes The effects of preoperative statin treatment on acute kidney injury (AKI) remain controversial, and current clinical evidence regarding statin use in the elderly undergoing valve replacement surgery (VRS) is insufficient. The present study aimed to investigate the association between preoperative statin treatment and AKI after VRS in the elderly. Methods Three thousand seven hundred ninety-one elderly patients (≥ 60 years) undergoing VRS were included in this study and divided into 2 groups, according to the receipt of statin treatment before the operation: statin users (n = 894) and non-users (n = 2897). We determined the associations between statin use, AKI, and other adverse events using a multivariate model and propensity score-matched analysis. Results After propensity score-matched analysis, there was no difference between statin users and non-users in regard to postoperative AKI (72.5% vs. 72.4%, p = 0.954), in-hospital death (5.7% vs. 5.1%, p = 0.650) and 1-year mortality (log-rank = 0, p = 0.986). The multivariate analysis showed that statin use was not an independent risk factor for postoperative AKI (OR = 0.97, 95% CI: 0.90–1.17, p = 0.733), in-hospital mortality (OR = 1.12, 95% CI: 0.75–1.68, p = 0.568), or 1-year mortality (HR = 0.95, 95% CI: 0.70–1.28, p = 0.715). Conclusion Preoperative statin treatment did not significantly affect the risk of AKI among elderly patients undergoing VRS..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:78
Enthalten in:	European journal of clinical pharmacology - 78(2021), 3 vom: 23. Nov., Seite 505-512

Sprache:	Englisch

Beteiligte Personen:	Fu, Bing-qi [VerfasserIn] Wei, Xue-biao [VerfasserIn] Su, Zedazhong [VerfasserIn] Lin, Ying-wen [VerfasserIn] Ke, Zu-hui [VerfasserIn] Tan, Tong [VerfasserIn] Chen, Ji-yan [VerfasserIn] Wang, Shou-hong [VerfasserIn] Yu, Dan-qing [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Acute kidney injury Elderly patient Prevention Statin Valve replacement surgery

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021

doi:	10.1007/s00228-021-03252-4

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2129337228

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520			\|a Purposes The effects of preoperative statin treatment on acute kidney injury (AKI) remain controversial, and current clinical evidence regarding statin use in the elderly undergoing valve replacement surgery (VRS) is insufficient. The present study aimed to investigate the association between preoperative statin treatment and AKI after VRS in the elderly. Methods Three thousand seven hundred ninety-one elderly patients (≥ 60 years) undergoing VRS were included in this study and divided into 2 groups, according to the receipt of statin treatment before the operation: statin users (n = 894) and non-users (n = 2897). We determined the associations between statin use, AKI, and other adverse events using a multivariate model and propensity score-matched analysis. Results After propensity score-matched analysis, there was no difference between statin users and non-users in regard to postoperative AKI (72.5% vs. 72.4%, p = 0.954), in-hospital death (5.7% vs. 5.1%, p = 0.650) and 1-year mortality (log-rank = 0, p = 0.986). The multivariate analysis showed that statin use was not an independent risk factor for postoperative AKI (OR = 0.97, 95% CI: 0.90–1.17, p = 0.733), in-hospital mortality (OR = 1.12, 95% CI: 0.75–1.68, p = 0.568), or 1-year mortality (HR = 0.95, 95% CI: 0.70–1.28, p = 0.715). Conclusion Preoperative statin treatment did not significantly affect the risk of AKI among elderly patients undergoing VRS.
650		4	\|a Valve replacement surgery
650		4	\|a Statin
650		4	\|a Acute kidney injury
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The effect of preoperative statin treatment on acute kidney injury in elderly patients undergoing valve replacement surgery

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