Role of YB-1 in Regulation of Poly(ADP-Ribosylation) Catalyzed by Poly(ADP-Ribose) Polymerases
Abstract Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability..
Medienart: |
Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:87 |
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Enthalten in: |
Biochemistry - 87(2022), Suppl 1 vom: Jan., Seite S32-S47 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Alemasova, Elizaveta E. [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
Poly(ADP-ribose) (PAR) |
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Anmerkungen: |
© Pleiades Publishing, Ltd. 2022 |
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doi: |
10.1134/S0006297922140048 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2129260993 |
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520 | |a Abstract Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymerase 1 (PARP1). Understanding the mechanisms of the PARP1 activity regulation within the cells is necessary for development of the PARP1-targeted antitumor therapy. This review is devoted to the studies of the role of the RNA-binding protein YB-1 in the PARP1-catalyzed PARylation. The mechanisms of PARP1 activity stimulation by YB-1 protein can possibly be extended to other RNA-binding proteins involved in the maintenance of the genome stability. | ||
650 | 4 | |a Y-box-binding protein 1 (YB-1) | |
650 | 4 | |a poly(ADP-ribosyl)ation (PARylation) | |
650 | 4 | |a poly(ADP-ribose) (PAR) | |
650 | 4 | |a poly(ADP-ribose) polymerase 1 (PARP1) | |
650 | 4 | |a RNA-binding protein (RBP) | |
700 | 1 | |a Naumenko, Konstantin N. |4 aut | |
700 | 1 | |a Sukhanova, Maria V. |4 aut | |
700 | 1 | |a Lavrik, Olga I. |4 aut | |
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