Details der Publikation - Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus

Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus

Background Obesity and diabetes prevalence are increasing worldwide. We aimed to detect the possible association of osteoprotegerin (OPG) gene expression with visceral adiposity indices and cardiometabolic risk factors among obese women. Methods and results The study enrolled 150 controls and 150 obese cases subdivided into two subgroups non-diabetic (n = 70) and 80 patients with type 2 diabetes mellitus (T2DM). Circulating OPG gene expression levels were figured out by real time PCR (Polymerase Chain Reaction). Serum OPG levels were assessed by Enzyme Linked Immunosorbent Assay. Our results explored that OPG serum levels were lower in the obese women compared to control group (p < 0.001) and obese diabetics had higher serum levels of OPG in comparison to obese non-diabetic patients (p < 0.001). Expression levels of OPG were higher in obese women than controls (p < 0.001). Moreover, the blood expression levels of OPG gene were higher in diabetic obese patients than non-diabetics. We found positive correlations between parameters of metabolic syndrome and obesity indices. After adjustment of the traditional risk factors, stepwise linear regression analysis test revealed that OPG expression levels were independently correlated with glycated hemoglobin, high-density lipoprotein-cholesterol, and waist-to-hip ratio. Conclusions OPG mRNA levels were associated with surrogate markers of insulin resistance in Egyptian obese women..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:48
Enthalten in:	Molecular biology reports - 48(2021), 11 vom: 06. Sept., Seite 7095-7104

Sprache:	Englisch

Beteiligte Personen:	Rashad, Nearmeen M. [VerfasserIn] El-Shal, Amal S. [VerfasserIn] Shalaby, Sally M. [VerfasserIn] Abdel-Nour, Hanim M. [VerfasserIn] Sarhan, Walaa M. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	42.13$jMolekularbiologie
Themen:	Diabetes mellitus Metabolic syndrome Obesity Osteoprotegerin Real time polymerase chain reaction Type 2 diabetes mellitus

Anmerkungen:	© The Author(s), under exclusive licence to Springer Nature B.V. 2021

doi:	10.1007/s11033-021-06699-x

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2128374154

Internformat


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520			\|a Background Obesity and diabetes prevalence are increasing worldwide. We aimed to detect the possible association of osteoprotegerin (OPG) gene expression with visceral adiposity indices and cardiometabolic risk factors among obese women. Methods and results The study enrolled 150 controls and 150 obese cases subdivided into two subgroups non-diabetic (n = 70) and 80 patients with type 2 diabetes mellitus (T2DM). Circulating OPG gene expression levels were figured out by real time PCR (Polymerase Chain Reaction). Serum OPG levels were assessed by Enzyme Linked Immunosorbent Assay. Our results explored that OPG serum levels were lower in the obese women compared to control group (p < 0.001) and obese diabetics had higher serum levels of OPG in comparison to obese non-diabetic patients (p < 0.001). Expression levels of OPG were higher in obese women than controls (p < 0.001). Moreover, the blood expression levels of OPG gene were higher in diabetic obese patients than non-diabetics. We found positive correlations between parameters of metabolic syndrome and obesity indices. After adjustment of the traditional risk factors, stepwise linear regression analysis test revealed that OPG expression levels were independently correlated with glycated hemoglobin, high-density lipoprotein-cholesterol, and waist-to-hip ratio. Conclusions OPG mRNA levels were associated with surrogate markers of insulin resistance in Egyptian obese women.
650		4	\|a Type 2 diabetes mellitus
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Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus

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