Details der Publikation - Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York

Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York

Abstract It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/$ m^{2} $. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/$ m^{2} $ and BMI ≥40 kg/$ m^{2} $ were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/$ m^{2} $ was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted..

Medienart:	Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:40
Enthalten in:	European journal of clinical microbiology & infectious diseases - 40(2021), 9 vom: 06. Mai, Seite 1963-1974

Sprache:	Englisch

Beteiligte Personen:	Guerson-Gil, Arcelia [VerfasserIn] Palaiodimos, Leonidas [VerfasserIn] Assa, Andrei [VerfasserIn] Karamanis, Dimitris [VerfasserIn] Kokkinidis, Damianos [VerfasserIn] Chamorro-Pareja, Natalia [VerfasserIn] Kishore, Preeti [VerfasserIn] Leider, Jason M. [VerfasserIn] Brandt, Lawrence J. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	COVID-19 IL-6 Inflammation Mortality Novel coronavirus Obesity Observational study Risk factor SARS-CoV-2

RVK:	RVK Klassifikation ELIB24 ELIB09

Anmerkungen:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021

doi:	10.1007/s10096-021-04260-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2127080602

Internformat


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520			\|a Abstract It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/$ m^{2} $. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/$ m^{2} $ and BMI ≥40 kg/$ m^{2} $ were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/$ m^{2} $ was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.
650		4	\|a COVID-19
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650		4	\|a Novel coronavirus
650		4	\|a Obesity
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650		4	\|a IL-6
650		4	\|a Mortality
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700	1		\|a Palaiodimos, Leonidas \|4 aut
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700	1		\|a Karamanis, Dimitris \|4 aut
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700	1		\|a Chamorro-Pareja, Natalia \|4 aut
700	1		\|a Kishore, Preeti \|4 aut
700	1		\|a Leider, Jason M. \|4 aut
700	1		\|a Brandt, Lawrence J. \|4 aut
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Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York

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