Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York
Abstract It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/$ m^{2} $. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/$ m^{2} $ and BMI ≥40 kg/$ m^{2} $ were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/$ m^{2} $ was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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Enthalten in: |
European journal of clinical microbiology & infectious diseases - 40(2021), 9 vom: 06. Mai, Seite 1963-1974 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Guerson-Gil, Arcelia [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
COVID-19 |
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RVK: |
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Anmerkungen: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 |
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doi: |
10.1007/s10096-021-04260-z |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2127080599 |
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520 | |a Abstract It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/$ m^{2} $. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/$ m^{2} $ and BMI ≥40 kg/$ m^{2} $ were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/$ m^{2} $ was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted. | ||
650 | 4 | |a COVID-19 | |
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650 | 4 | |a Novel coronavirus | |
650 | 4 | |a Obesity | |
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700 | 1 | |a Palaiodimos, Leonidas |4 aut | |
700 | 1 | |a Assa, Andrei |4 aut | |
700 | 1 | |a Karamanis, Dimitris |4 aut | |
700 | 1 | |a Kokkinidis, Damianos |4 aut | |
700 | 1 | |a Chamorro-Pareja, Natalia |4 aut | |
700 | 1 | |a Kishore, Preeti |4 aut | |
700 | 1 | |a Leider, Jason M. |4 aut | |
700 | 1 | |a Brandt, Lawrence J. |4 aut | |
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