Details der Publikation - Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity

Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity

Abstract The structure of complex cis-Pd(HLMe)Cl2 was studied both in solution and in solid state using multinuclear (1H, 13C, 15N) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HLMe)Cl2 has a pronounced cytotoxicity toward human leukemic lymphoblast’s CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HLMe)Cl2 is more toxic than cisplatin: its $ IC_{50} $ value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin $ IC_{50} $. Depending on the concentration, cis-Pd(HLMe)Cl2 is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HLMe)Cl2 suggest the dependence of the agent’s interactions with cells on the molecular structure of palladium ligand and the cell type..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:75
Enthalten in:	Chemical papers - 75(2021), 9 vom: 29. Mai, Seite 4899-4906

Sprache:	Englisch

Beteiligte Personen:	Zakharchenko, Borys V. [VerfasserIn] Khomenko, Dmytro M. [VerfasserIn] Doroschuk, Roman O. [VerfasserIn] Raspertova, Ilona V. [VerfasserIn] Shova, Sergiu [VerfasserIn] Grebinyk, Anna G. [VerfasserIn] Grynyuk, Iryna I. [VerfasserIn] Prylutska, Svitlana V. [VerfasserIn] Matyshevska, Olga P. [VerfasserIn] Slobodyanik, Mykola S. [VerfasserIn] Frohme, Marcus [VerfasserIn] Lampeka, Rostislav D. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	1,2,4-Triazole Cancer cells Cytotoxicity Hemolysis of erythrocytes NMR spectroscopy Palladium

Anmerkungen:	© Institute of Chemistry, Slovak Academy of Sciences 2021

doi:	10.1007/s11696-021-01699-4

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC212679248X

Internformat


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520			\|a Abstract The structure of complex cis-Pd(HLMe)Cl2 was studied both in solution and in solid state using multinuclear (1H, 13C, 15N) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HLMe)Cl2 has a pronounced cytotoxicity toward human leukemic lymphoblast’s CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HLMe)Cl2 is more toxic than cisplatin: its $ IC_{50} $ value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin $ IC_{50} $. Depending on the concentration, cis-Pd(HLMe)Cl2 is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HLMe)Cl2 suggest the dependence of the agent’s interactions with cells on the molecular structure of palladium ligand and the cell type.
650		4	\|a Palladium
650		4	\|a 1,2,4-Triazole
650		4	\|a NMR spectroscopy
650		4	\|a Cytotoxicity
650		4	\|a Cancer cells
650		4	\|a Hemolysis of erythrocytes
700	1		\|a Khomenko, Dmytro M. \|4 aut
700	1		\|a Doroschuk, Roman O. \|4 aut
700	1		\|a Raspertova, Ilona V. \|0 (orcid)0000-0002-2382-063X \|4 aut
700	1		\|a Shova, Sergiu \|4 aut
700	1		\|a Grebinyk, Anna G. \|4 aut
700	1		\|a Grynyuk, Iryna I. \|4 aut
700	1		\|a Prylutska, Svitlana V. \|4 aut
700	1		\|a Matyshevska, Olga P. \|4 aut
700	1		\|a Slobodyanik, Mykola S. \|4 aut
700	1		\|a Frohme, Marcus \|4 aut
700	1		\|a Lampeka, Rostislav D. \|4 aut
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Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity

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