Details der Publikation - Microbiology of parapharyngeal abscesses in adults: in search of the significant pathogens

Microbiology of parapharyngeal abscesses in adults: in search of the significant pathogens

Abstract We aimed to describe the microbiology of parapharyngeal abscess (PPA) and point out the likely pathogens using the following principles to suggest pathogenic significance: (1) frequent recovery, (2) abundant growth, (3) growth in relative abundance to other microorganisms, (4) percentage of the isolates recovered in both absolute and relative abundance, (5) more frequent recovery in PPA pus compared with tonsillar surface and tissue. Comprehensive bacterial cultures were performed on specimens obtained from adult patients (n = 60) with surgically verified PPA, who were prospectively enrolled at five Danish ear-nose-throat departments. The prevalent isolates (in PPA pus) were unspecified anaerobes (73%), non-hemolytic streptococci (67%), Streptococcus anginosus group (SAG) (40%), Corynebacterium spp. (25%), Neisseria spp. (23%), Fusobacterium spp. (22%), Fusobacterium necrophorum (17%), Prevotella spp. (12%), and Streptococcus pyogenes (10%). The bacteria most frequently isolated in heavy (maximum) growth were unspecified anaerobes (60%), SAG (40%), F. necrophorum (23%), and Prevotella spp. (17%). The predominant microorganisms (those found in highest relative abundance) were unspecified anaerobes (53%), SAG (28%), non-hemolytic streptococci (25%), F. necrophorum (15%), S. pyogenes (10%), and Prevotella spp. (10%). Four potential pathogens were found in both heavy growth and highest relative abundance in at least 50% of cases: F. necrophorum, Prevotella spp., SAG, and S. pyogenes. SAG, Prevotella spp., F. necrophorum, S. pyogenes, and Bacteroides spp. were recovered with the same or higher frequency from PPA pus compared with tonsillar tissue and surface. Our findings suggest that SAG, F. necrophorum, Prevotella, and S. pyogenes are significant pathogens in PPA development..

Medienart:	Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:40
Enthalten in:	European journal of clinical microbiology & infectious diseases - 40(2021), 7 vom: 10. Feb., Seite 1461-1470

Sprache:	Englisch

Beteiligte Personen:	Klug, Tejs Ehlers [VerfasserIn] Greve, Thomas [VerfasserIn] Andersen, Camilla [VerfasserIn] Hahn, Pernille [VerfasserIn] Danstrup, Christian [VerfasserIn] Petersen, Niels Krintel [VerfasserIn] Ninn-Pedersen, Mirjana [VerfasserIn] Mikkelsen, Sophie [VerfasserIn] Pauli, Søren [VerfasserIn] Fuglsang, Simon [VerfasserIn] Døssing, Helle [VerfasserIn] Christensen, Anne-Louise [VerfasserIn] Rusan, Maria [VerfasserIn] Kjeldsen, Anette [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Microbiology Parapharyngeal abscess Pathogens

RVK:	RVK Klassifikation ELIB24 ELIB09

Anmerkungen:	© The Author(s) 2021

doi:	10.1007/s10096-021-04180-y

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2126084914

Internformat


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520			\|a Abstract We aimed to describe the microbiology of parapharyngeal abscess (PPA) and point out the likely pathogens using the following principles to suggest pathogenic significance: (1) frequent recovery, (2) abundant growth, (3) growth in relative abundance to other microorganisms, (4) percentage of the isolates recovered in both absolute and relative abundance, (5) more frequent recovery in PPA pus compared with tonsillar surface and tissue. Comprehensive bacterial cultures were performed on specimens obtained from adult patients (n = 60) with surgically verified PPA, who were prospectively enrolled at five Danish ear-nose-throat departments. The prevalent isolates (in PPA pus) were unspecified anaerobes (73%), non-hemolytic streptococci (67%), Streptococcus anginosus group (SAG) (40%), Corynebacterium spp. (25%), Neisseria spp. (23%), Fusobacterium spp. (22%), Fusobacterium necrophorum (17%), Prevotella spp. (12%), and Streptococcus pyogenes (10%). The bacteria most frequently isolated in heavy (maximum) growth were unspecified anaerobes (60%), SAG (40%), F. necrophorum (23%), and Prevotella spp. (17%). The predominant microorganisms (those found in highest relative abundance) were unspecified anaerobes (53%), SAG (28%), non-hemolytic streptococci (25%), F. necrophorum (15%), S. pyogenes (10%), and Prevotella spp. (10%). Four potential pathogens were found in both heavy growth and highest relative abundance in at least 50% of cases: F. necrophorum, Prevotella spp., SAG, and S. pyogenes. SAG, Prevotella spp., F. necrophorum, S. pyogenes, and Bacteroides spp. were recovered with the same or higher frequency from PPA pus compared with tonsillar tissue and surface. Our findings suggest that SAG, F. necrophorum, Prevotella, and S. pyogenes are significant pathogens in PPA development.
650		4	\|a Parapharyngeal abscess
650		4	\|a Microbiology
650		4	\|a Pathogens
700	1		\|a Greve, Thomas \|4 aut
700	1		\|a Andersen, Camilla \|4 aut
700	1		\|a Hahn, Pernille \|4 aut
700	1		\|a Danstrup, Christian \|4 aut
700	1		\|a Petersen, Niels Krintel \|4 aut
700	1		\|a Ninn-Pedersen, Mirjana \|4 aut
700	1		\|a Mikkelsen, Sophie \|4 aut
700	1		\|a Pauli, Søren \|4 aut
700	1		\|a Fuglsang, Simon \|4 aut
700	1		\|a Døssing, Helle \|4 aut
700	1		\|a Christensen, Anne-Louise \|4 aut
700	1		\|a Rusan, Maria \|4 aut
700	1		\|a Kjeldsen, Anette \|4 aut
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Microbiology of parapharyngeal abscesses in adults: in search of the significant pathogens

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