Details der Publikation - Flavonoids in the Treatment of Neuropathic Pain

Flavonoids in the Treatment of Neuropathic Pain

Purpose of Review Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain. Recent Findings Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Summary Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time..

Medienart:	E-Artikel

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	Zur Gesamtaufnahme - volume:25
Enthalten in:	Current pain and headache reports - 25(2021), 7 vom: 07. Mai

Sprache:	Englisch

Beteiligte Personen:	Rao, Prashant N. [VerfasserIn] Mainkar, Ojas [VerfasserIn] Bansal, Nitin [VerfasserIn] Rakesh, Neal [VerfasserIn] Haffey, Paul [VerfasserIn] Urits, Ivan [VerfasserIn] Orhurhu, Vwaire [VerfasserIn] Kaye, Alan D. [VerfasserIn] Urman, Richard D. [VerfasserIn] Gulati, Amitabh [VerfasserIn] Jones, Mark [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.90$jNeurologie
Themen:	Chronic pain Flavonoids Neuroinflammation Neuropathic pain Treatment

Anmerkungen:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021

doi:	10.1007/s11916-021-00959-y

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2125339099

Internformat


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520			\|a Purpose of Review Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain. Recent Findings Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Summary Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.
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Flavonoids in the Treatment of Neuropathic Pain

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