Probing the Interface of HIV and Inflammaging
Purpose of Review Systemic inflammation increases as a consequence of aging (inflammaging) and contributes to age-related morbidities. Inflammation in people living with HIV is elevated compared with the general population even after prolonged suppression of viremia with anti-retroviral therapy. Mechanisms that contribute to inflammation during aging and in treated HIV disease are potentially interactive, leading to an exaggerated inflammatory phenotype in people with HIV. Recent Findings Recent studies highlight roles for anti-retroviral therapy, co-infections, immune system alterations, and microbiome perturbations as important contributors to HIV-associated inflammation. These factors likely contribute to increased risk of age-related morbidities in people living with HIV. Summary Understanding mechanisms that exaggerate the inflammaging process in people with HIV may lead to improved intervention strategies, ultimately, extending both lifespan and healthspan..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
|---|---|
| Enthalten in: |
Current HIV AIDS reports - 18(2021), 3 vom: 11. März, Seite 198-210 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sieg, Scott F. [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021 |
|---|
| doi: |
10.1007/s11904-021-00547-0 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC212501338X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC212501338X | ||
| 003 | DE-627 | ||
| 005 | 20230505094437.0 | ||
| 007 | tu | ||
| 008 | 230505s2021 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11904-021-00547-0 |2 doi | |
| 035 | |a (DE-627)OLC212501338X | ||
| 035 | |a (DE-He213)s11904-021-00547-0-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Sieg, Scott F. |e verfasserin |0 (orcid)0000-0002-1769-8682 |4 aut | |
| 245 | 1 | 0 | |a Probing the Interface of HIV and Inflammaging |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021 | ||
| 520 | |a Purpose of Review Systemic inflammation increases as a consequence of aging (inflammaging) and contributes to age-related morbidities. Inflammation in people living with HIV is elevated compared with the general population even after prolonged suppression of viremia with anti-retroviral therapy. Mechanisms that contribute to inflammation during aging and in treated HIV disease are potentially interactive, leading to an exaggerated inflammatory phenotype in people with HIV. Recent Findings Recent studies highlight roles for anti-retroviral therapy, co-infections, immune system alterations, and microbiome perturbations as important contributors to HIV-associated inflammation. These factors likely contribute to increased risk of age-related morbidities in people living with HIV. Summary Understanding mechanisms that exaggerate the inflammaging process in people with HIV may lead to improved intervention strategies, ultimately, extending both lifespan and healthspan. | ||
| 650 | 4 | |a HIV disease | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Aging | |
| 700 | 1 | |a Shive, Carey L. |4 aut | |
| 700 | 1 | |a Panigrahi, Soumya |4 aut | |
| 700 | 1 | |a Freeman, Michael L. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current HIV AIDS reports |d Springer US, 2004 |g 18(2021), 3 vom: 11. März, Seite 198-210 |w (DE-627)390611921 |w (DE-600)2151206-1 |x 1548-3568 |7 nnns |
| 773 | 1 | 8 | |g volume:18 |g year:2021 |g number:3 |g day:11 |g month:03 |g pages:198-210 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s11904-021-00547-0 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 951 | |a AR | ||
| 952 | |d 18 |j 2021 |e 3 |b 11 |c 03 |h 198-210 | ||