The antioxidant N-(2-mercaptopropionyl)-glycine (tiopronin) attenuates expression of neuropathic allodynia and hyperalgesia

Abstract The current pharmacotherapy of neuropathic pain is inadequate as neuropathic pain involves varied clinical manifestations with multifactorial etiology, modulated by a cascade of physical and molecular events leading to different clinical presentations of pain. There is an accumulating evidence of the involvement of oxidative stress in neuropathy, and antioxidants have shown promise in mitigating neuropathic pain syndromes. To explore the evidence supporting this beneficial proclivity of antioxidants, this study investigated the antinociceptive effectiveness of N-(2-mercaptopropionyl)glycine or tiopronin, a well-recognized aminothiol antioxidant, in a refined chronic constriction injury (CCI) rat model of neuropathic pain. Tiopronin (10, 30, and 90 mg/kg, i.p.) and pregabalin (30 mg/kg, i.p.) were administered daily after CCI surgery. The neuropathic paradigms of mechanical/cold allodynia and mechanical/heat hyperalgesia were assessed on days 3, 7, 14, and 21 post-nerve ligation. At the end of study, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) levels were estimated in the sciatic nerve, dorsal root ganglion, and spinal cord for assessing the extent of oxidative stress. The expression of neuropathic nociception was attenuated by tiopronin which was observed as a significant attenuation of CCI-induced allodynia and hyperalgesia. Tiopronin reversed the neuronal oxidative stress by significantly reducing MDA, and increasing SOD, CAT, and GSH levels. Pregabalin also showed similar beneficial propensity on CCI-induced neuropathic aberrations. These findings suggest prospective neuropathic pain attenuating efficacy of tiopronin and further corroborated the notion that antioxidants are effective in mitigating the development and expression of neuropathic pain and underlying neuronal oxidative stress..

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:394

Enthalten in:

Naunyn-Schmiedeberg's archives of pharmacology - 394(2020), 4 vom: 20. Okt., Seite 603-617

Sprache:

Englisch

Beteiligte Personen:

Shahid, Muhammad [VerfasserIn]
Subhan, Fazal [VerfasserIn]
Islam, Nazar Ul [VerfasserIn]
Ahmad, Nisar [VerfasserIn]
Farooq, Umar [VerfasserIn]
Abbas, Sudhair [VerfasserIn]
Akbar, Shehla [VerfasserIn]
Ullah, Ihsan [VerfasserIn]
Raziq, Naila [VerfasserIn]
Din, Zia Ud [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Analgesia
Chronic constriction injury
Neuropathic pain
Nociception
Oxidative stress

Anmerkungen:

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

doi:

10.1007/s00210-020-01995-y

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2124653903

Zugang & Verfügbarkeit




Zugehörige Publikationen/Bände

    Haven't found what you're looking for?