Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms
Purpose To evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival secretions from patients without ocular symptoms. Methods Conjunctival swabs were prospectively collected from laboratory-confirmed Coronavirus disease 2019 (COVID-19) patients without ocular symptoms for reverse transcription-polymerase chain reaction (RT-PCR) and viral culture. Results A total of 158 conjunctival swabs were obtained from 49 laboratory-confirmed COVID-19 patients. The median duration of illness when the first conjunctival swab was obtained was 10 days (range 2–27 days). Four conjunctival swabs from four different patients (4/49, 8.2%) were positive for SARS-CoV-2 RNA by RT-PCR. The Ct values ranged from 32.7 to 37.7 (mean 35.4). Viral cultures were negative for all four RT-PCR-positive conjunctival swabs. Conclusion Conjunctival secretions of a minority of COVID-19 patients without ocular symptoms may contain relatively low levels of SARS-CoV-2 RNA, but their infectiousness remains undetermined. Appropriate infection control measures should be implemented during ophthalmological assessment of COVID-19 patients to prevent potential nosocomial transmission of SARS-CoV-2..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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Enthalten in: |
Infection - 49(2020), 2 vom: 17. Sept., Seite 257-265 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Li, Xin [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Anmerkungen: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2020 |
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doi: |
10.1007/s15010-020-01524-2 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2124578472 |
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520 | |a Purpose To evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival secretions from patients without ocular symptoms. Methods Conjunctival swabs were prospectively collected from laboratory-confirmed Coronavirus disease 2019 (COVID-19) patients without ocular symptoms for reverse transcription-polymerase chain reaction (RT-PCR) and viral culture. Results A total of 158 conjunctival swabs were obtained from 49 laboratory-confirmed COVID-19 patients. The median duration of illness when the first conjunctival swab was obtained was 10 days (range 2–27 days). Four conjunctival swabs from four different patients (4/49, 8.2%) were positive for SARS-CoV-2 RNA by RT-PCR. The Ct values ranged from 32.7 to 37.7 (mean 35.4). Viral cultures were negative for all four RT-PCR-positive conjunctival swabs. Conclusion Conjunctival secretions of a minority of COVID-19 patients without ocular symptoms may contain relatively low levels of SARS-CoV-2 RNA, but their infectiousness remains undetermined. Appropriate infection control measures should be implemented during ophthalmological assessment of COVID-19 patients to prevent potential nosocomial transmission of SARS-CoV-2. | ||
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a Conjunctiva | |
650 | 4 | |a Asymptomatic | |
650 | 4 | |a Shedding | |
650 | 4 | |a RT-PCR | |
700 | 1 | |a Chan, Jasper Fuk-Woo |4 aut | |
700 | 1 | |a Li, Kenneth Kai-Wang |4 aut | |
700 | 1 | |a Tso, Eugene Yuk-Keung |4 aut | |
700 | 1 | |a Yip, Cyril Chik-Yan |4 aut | |
700 | 1 | |a Sridhar, Siddharth |4 aut | |
700 | 1 | |a Chung, Tom Wai-Hin |4 aut | |
700 | 1 | |a Chiu, Kelvin Hei-Yeung |4 aut | |
700 | 1 | |a Hung, Derek Ling-Lung |4 aut | |
700 | 1 | |a Wu, Alan Ka-Lun |4 aut | |
700 | 1 | |a Chau, Sandy Ka-Yee |4 aut | |
700 | 1 | |a Liu, Raymond |4 aut | |
700 | 1 | |a Lung, Kwok-Cheung |4 aut | |
700 | 1 | |a Tam, Anthony Raymond |4 aut | |
700 | 1 | |a Cheng, Vincent Chi-Chung |4 aut | |
700 | 1 | |a To, Kelvin Kai-Wang |4 aut | |
700 | 1 | |a Chan, Kwok-Hung |4 aut | |
700 | 1 | |a Hung, Ivan Fan-Ngai |4 aut | |
700 | 1 | |a Yuen, Kwok-Yung |4 aut | |
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