1H, 15N and 13C resonance assignments of the N-terminal domain of the nucleocapsid protein from the endemic human coronavirus HKU1
Abstract Coronaviruses have become of great medical and scientific interest because of the Covid-19 pandemic. The hCoV-HKU1 is an endemic betacoronavirus that causes mild respiratory symptoms, although the infection can progress to severe lung disease and death. During viral replication, a discontinuous transcription of the genome takes place, producing the subgenomic messenger RNAs. The nucleocapsid protein (N) plays a pivotal role in the regulation of this process, acting as an RNA chaperone and participating in the nucleocapsid assembly. The isolated N-terminal domain of protein N (N-NTD) specifically binds to the transcriptional regulatory sequences and control the melting of the double-stranded RNA. Here, we report the resonance assignments of the N-NTD of HKU1-CoV..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Biomolecular NMR assignments - 15(2021), 1 vom: 03. Jan., Seite 153-157 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Luna Marques, Aline [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
HKU1 |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 |
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| doi: |
10.1007/s12104-020-09998-9 |
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| funding: |
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| PPN (Katalog-ID): |
OLC2124453475 |
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| 520 | |a Abstract Coronaviruses have become of great medical and scientific interest because of the Covid-19 pandemic. The hCoV-HKU1 is an endemic betacoronavirus that causes mild respiratory symptoms, although the infection can progress to severe lung disease and death. During viral replication, a discontinuous transcription of the genome takes place, producing the subgenomic messenger RNAs. The nucleocapsid protein (N) plays a pivotal role in the regulation of this process, acting as an RNA chaperone and participating in the nucleocapsid assembly. The isolated N-terminal domain of protein N (N-NTD) specifically binds to the transcriptional regulatory sequences and control the melting of the double-stranded RNA. Here, we report the resonance assignments of the N-NTD of HKU1-CoV. | ||
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| 700 | 1 | |a Almeida, Fabio Ceneviva Lacerda |0 (orcid)0000-0001-6046-7006 |4 aut | |
| 700 | 1 | |a Amorim, Gisele Cardoso |0 (orcid)0000-0003-4348-9515 |4 aut | |
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