The role of diffusion-weighted MRI and contrast-enhanced MRI for differentiation between solid renal masses and renal cell carcinoma subtypes
Purpose To assess the value of diffusion-weighted magnetic resonance imaging (DW-MRI) and contrast-enhanced MRI (CE-MRI) for differentiation between benign and malignant solid renal masses, renal cell carcinoma (RCC) subtypes, oncocytomas, and lipid-poor angiomyolipomas (LP-AML). Methods Minimum or lowest ‘apparent diffusion coefficient’ ($ ADC_{1} $) and representative ADC values ($ ADC_{2} $) of 112 renal masses (n: 46 benign renal mass, n: 66 malignant renal mass) were measured on DW-MRI images (b 50, 400, 800 s/$ mm^{2} $). Signal intensity (SI) measurements were performed in normal renal parenchyma and most avid enhanced area of the renal masses at precontrast, corticomedullary, and nephrographic phases on CE-MRI. Contrast enhancement rate (CER) and contrast enhancement index (CEI) values of renal masses were compared between benign-malignant renal masses and RCC subtypes, oncocytomas, and LP-AMLs. Results There was no significant difference between $ ADC_{1} $, $ ADC_{2} $ values, and SI of benign and malignant renal masses (p = 0.721, p = 0.255, p = 0.872). Mean $ ADC_{1} $ and $ ADC_{2} $ values of clear cell RCCs were significantly higher than nonclear cell RCCs (p = 0.005 p = 0.002). Mean CER value of clear cell RCCs was significantly higher than nonclear cell RCCs in nephrographic phase (p = 0.003). Mean CEI values of clear cell RCCs were significantly higher than nonclear cell RCCs in the corticomedullary and nephrographic phase (p = 0.027 vs. 0.008). LP-AMLs were differentiated from other renal masses with wash-out phenomenon. Conclusion Combined usage of ADC, SI, CER, and CEI values may be useful for discrimination between RCC subtypes, oncocytomas, and lipid-poor AMLs..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Abdominal radiology - 46(2020), 3 vom: 15. Sept., Seite 1041-1052 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Serter, Aslı [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Benign neoplasms |
|---|
| Anmerkungen: |
© Springer Science+Business Media, LLC, part of Springer Nature 2020 |
|---|
| doi: |
10.1007/s00261-020-02742-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2124220101 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2124220101 | ||
| 003 | DE-627 | ||
| 005 | 20230505084618.0 | ||
| 007 | tu | ||
| 008 | 230505s2020 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00261-020-02742-w |2 doi | |
| 035 | |a (DE-627)OLC2124220101 | ||
| 035 | |a (DE-He213)s00261-020-02742-w-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 100 | 1 | |a Serter, Aslı |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a The role of diffusion-weighted MRI and contrast-enhanced MRI for differentiation between solid renal masses and renal cell carcinoma subtypes |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer Science+Business Media, LLC, part of Springer Nature 2020 | ||
| 520 | |a Purpose To assess the value of diffusion-weighted magnetic resonance imaging (DW-MRI) and contrast-enhanced MRI (CE-MRI) for differentiation between benign and malignant solid renal masses, renal cell carcinoma (RCC) subtypes, oncocytomas, and lipid-poor angiomyolipomas (LP-AML). Methods Minimum or lowest ‘apparent diffusion coefficient’ ($ ADC_{1} $) and representative ADC values ($ ADC_{2} $) of 112 renal masses (n: 46 benign renal mass, n: 66 malignant renal mass) were measured on DW-MRI images (b 50, 400, 800 s/$ mm^{2} $). Signal intensity (SI) measurements were performed in normal renal parenchyma and most avid enhanced area of the renal masses at precontrast, corticomedullary, and nephrographic phases on CE-MRI. Contrast enhancement rate (CER) and contrast enhancement index (CEI) values of renal masses were compared between benign-malignant renal masses and RCC subtypes, oncocytomas, and LP-AMLs. Results There was no significant difference between $ ADC_{1} $, $ ADC_{2} $ values, and SI of benign and malignant renal masses (p = 0.721, p = 0.255, p = 0.872). Mean $ ADC_{1} $ and $ ADC_{2} $ values of clear cell RCCs were significantly higher than nonclear cell RCCs (p = 0.005 p = 0.002). Mean CER value of clear cell RCCs was significantly higher than nonclear cell RCCs in nephrographic phase (p = 0.003). Mean CEI values of clear cell RCCs were significantly higher than nonclear cell RCCs in the corticomedullary and nephrographic phase (p = 0.027 vs. 0.008). LP-AMLs were differentiated from other renal masses with wash-out phenomenon. Conclusion Combined usage of ADC, SI, CER, and CEI values may be useful for discrimination between RCC subtypes, oncocytomas, and lipid-poor AMLs. | ||
| 650 | 4 | |a Kidney | |
| 650 | 4 | |a Diffusion-weighted MRI | |
| 650 | 4 | |a Magnetization transfer contrast imaging | |
| 650 | 4 | |a Benign neoplasms | |
| 650 | 4 | |a Malignant neoplasms | |
| 700 | 1 | |a Onur, Mehmet Ruhi |0 (orcid)0000-0003-1732-7862 |4 aut | |
| 700 | 1 | |a Coban, Ganime |0 (orcid)0000-0002-5779-6797 |4 aut | |
| 700 | 1 | |a Yildiz, Pelin |0 (orcid)0000-0002-7709-7264 |4 aut | |
| 700 | 1 | |a Armagan, Abdullah |4 aut | |
| 700 | 1 | |a Kocakoc, Ercan |0 (orcid)0000-0002-0060-3296 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Abdominal radiology |d Springer US, 2016 |g 46(2020), 3 vom: 15. Sept., Seite 1041-1052 |w (DE-627)840011903 |w (DE-600)2839786-1 |w (DE-576)451643356 |x 2366-004X |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2020 |g number:3 |g day:15 |g month:09 |g pages:1041-1052 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s00261-020-02742-w |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2020 |e 3 |b 15 |c 09 |h 1041-1052 | ||