The role of diffusion-weighted MRI and contrast-enhanced MRI for differentiation between solid renal masses and renal cell carcinoma subtypes
Purpose To assess the value of diffusion-weighted magnetic resonance imaging (DW-MRI) and contrast-enhanced MRI (CE-MRI) for differentiation between benign and malignant solid renal masses, renal cell carcinoma (RCC) subtypes, oncocytomas, and lipid-poor angiomyolipomas (LP-AML). Methods Minimum or lowest ‘apparent diffusion coefficient’ ($ ADC_{1} $) and representative ADC values ($ ADC_{2} $) of 112 renal masses (n: 46 benign renal mass, n: 66 malignant renal mass) were measured on DW-MRI images (b 50, 400, 800 s/$ mm^{2} $). Signal intensity (SI) measurements were performed in normal renal parenchyma and most avid enhanced area of the renal masses at precontrast, corticomedullary, and nephrographic phases on CE-MRI. Contrast enhancement rate (CER) and contrast enhancement index (CEI) values of renal masses were compared between benign-malignant renal masses and RCC subtypes, oncocytomas, and LP-AMLs. Results There was no significant difference between $ ADC_{1} $, $ ADC_{2} $ values, and SI of benign and malignant renal masses (p = 0.721, p = 0.255, p = 0.872). Mean $ ADC_{1} $ and $ ADC_{2} $ values of clear cell RCCs were significantly higher than nonclear cell RCCs (p = 0.005 p = 0.002). Mean CER value of clear cell RCCs was significantly higher than nonclear cell RCCs in nephrographic phase (p = 0.003). Mean CEI values of clear cell RCCs were significantly higher than nonclear cell RCCs in the corticomedullary and nephrographic phase (p = 0.027 vs. 0.008). LP-AMLs were differentiated from other renal masses with wash-out phenomenon. Conclusion Combined usage of ADC, SI, CER, and CEI values may be useful for discrimination between RCC subtypes, oncocytomas, and lipid-poor AMLs..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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Enthalten in: |
Abdominal radiology - 46(2020), 3 vom: 15. Sept., Seite 1041-1052 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Serter, Aslı [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
Benign neoplasms |
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Anmerkungen: |
© Springer Science+Business Media, LLC, part of Springer Nature 2020 |
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doi: |
10.1007/s00261-020-02742-w |
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funding: |
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PPN (Katalog-ID): |
OLC2124220098 |
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245 | 1 | 0 | |a The role of diffusion-weighted MRI and contrast-enhanced MRI for differentiation between solid renal masses and renal cell carcinoma subtypes |
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520 | |a Purpose To assess the value of diffusion-weighted magnetic resonance imaging (DW-MRI) and contrast-enhanced MRI (CE-MRI) for differentiation between benign and malignant solid renal masses, renal cell carcinoma (RCC) subtypes, oncocytomas, and lipid-poor angiomyolipomas (LP-AML). Methods Minimum or lowest ‘apparent diffusion coefficient’ ($ ADC_{1} $) and representative ADC values ($ ADC_{2} $) of 112 renal masses (n: 46 benign renal mass, n: 66 malignant renal mass) were measured on DW-MRI images (b 50, 400, 800 s/$ mm^{2} $). Signal intensity (SI) measurements were performed in normal renal parenchyma and most avid enhanced area of the renal masses at precontrast, corticomedullary, and nephrographic phases on CE-MRI. Contrast enhancement rate (CER) and contrast enhancement index (CEI) values of renal masses were compared between benign-malignant renal masses and RCC subtypes, oncocytomas, and LP-AMLs. Results There was no significant difference between $ ADC_{1} $, $ ADC_{2} $ values, and SI of benign and malignant renal masses (p = 0.721, p = 0.255, p = 0.872). Mean $ ADC_{1} $ and $ ADC_{2} $ values of clear cell RCCs were significantly higher than nonclear cell RCCs (p = 0.005 p = 0.002). Mean CER value of clear cell RCCs was significantly higher than nonclear cell RCCs in nephrographic phase (p = 0.003). Mean CEI values of clear cell RCCs were significantly higher than nonclear cell RCCs in the corticomedullary and nephrographic phase (p = 0.027 vs. 0.008). LP-AMLs were differentiated from other renal masses with wash-out phenomenon. Conclusion Combined usage of ADC, SI, CER, and CEI values may be useful for discrimination between RCC subtypes, oncocytomas, and lipid-poor AMLs. | ||
650 | 4 | |a Kidney | |
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650 | 4 | |a Benign neoplasms | |
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700 | 1 | |a Onur, Mehmet Ruhi |0 (orcid)0000-0003-1732-7862 |4 aut | |
700 | 1 | |a Coban, Ganime |0 (orcid)0000-0002-5779-6797 |4 aut | |
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700 | 1 | |a Armagan, Abdullah |4 aut | |
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