Details der Publikation - Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

Abstract C-reactive protein (CRP) has been studied extensively for association with a large number of non-infectious diseases and outcomes. We aimed to evaluate the breadth and validity of associations between CRP and non-infectious, chronic health outcomes and biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses and a systematic review of Mendelian randomization (MR) studies. PubMed, Scopus, and Cochrane Database of Systematic Reviews were systematically searched from inception up to March 2019. Meta-analyses of observational studies and MR studies examining associations between CRP and health outcomes were identified, excluding studies on the diagnostic value of CRP for infections. We found 113 meta-analytic comparisons of observational studies and 196 MR analyses, covering a wide range of outcomes. The overwhelming majority of the meta-analyses of observational studies reported a nominally statistically significant result (95/113, 84.1%); however, the majority of the meta-analyses displayed substantial heterogeneity (47.8%), small study effects (39.8%) or excess significance (41.6%). Only two outcomes, cardiovascular mortality and venous thromboembolism, showed convincing evidence of association with CRP levels. When examining the MR literature, we found MR studies for 53/113 outcomes examined in the observational study meta-analyses but substantial support for a causal association with CRP was not observed for any phenotype. Despite the striking amount of research on CRP, convincing evidence for associations and causal effects is remarkably limited..

Medienart:	E-Artikel

Erscheinungsjahr:	2020
Erschienen:	2020

Enthalten in:	Zur Gesamtaufnahme - volume:36
Enthalten in:	European journal of epidemiology - 36(2020), 1 vom: 25. Sept., Seite 11-36

Sprache:	Englisch

Beteiligte Personen:	Markozannes, Georgios [VerfasserIn] Koutsioumpa, Charalampia [VerfasserIn] Cividini, Sofia [VerfasserIn] Monori, Grace [VerfasserIn] Tsilidis, Konstantinos K. [VerfasserIn] Kretsavos, Nikolaos [VerfasserIn] Theodoratou, Evropi [VerfasserIn] Gill, Dipender [VerfasserIn] Ioannidis, John PA [VerfasserIn] Tzoulaki, Ioanna [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	44.11$jPräventivmedizin
Themen:	Bias C-reactive protein CRP Mendelian randomization Meta-analysis Systematic review Umbrella review

Anmerkungen:	© The Author(s) 2020

doi:	10.1007/s10654-020-00681-w

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2123159247

Internformat


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520			\|a Abstract C-reactive protein (CRP) has been studied extensively for association with a large number of non-infectious diseases and outcomes. We aimed to evaluate the breadth and validity of associations between CRP and non-infectious, chronic health outcomes and biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses and a systematic review of Mendelian randomization (MR) studies. PubMed, Scopus, and Cochrane Database of Systematic Reviews were systematically searched from inception up to March 2019. Meta-analyses of observational studies and MR studies examining associations between CRP and health outcomes were identified, excluding studies on the diagnostic value of CRP for infections. We found 113 meta-analytic comparisons of observational studies and 196 MR analyses, covering a wide range of outcomes. The overwhelming majority of the meta-analyses of observational studies reported a nominally statistically significant result (95/113, 84.1%); however, the majority of the meta-analyses displayed substantial heterogeneity (47.8%), small study effects (39.8%) or excess significance (41.6%). Only two outcomes, cardiovascular mortality and venous thromboembolism, showed convincing evidence of association with CRP levels. When examining the MR literature, we found MR studies for 53/113 outcomes examined in the observational study meta-analyses but substantial support for a causal association with CRP was not observed for any phenotype. Despite the striking amount of research on CRP, convincing evidence for associations and causal effects is remarkably limited.
650		4	\|a Umbrella review
650		4	\|a Meta-analysis
650		4	\|a Systematic review
650		4	\|a C-reactive protein
650		4	\|a CRP
650		4	\|a Mendelian randomization
650		4	\|a Bias
700	1		\|a Koutsioumpa, Charalampia \|4 aut
700	1		\|a Cividini, Sofia \|4 aut
700	1		\|a Monori, Grace \|4 aut
700	1		\|a Tsilidis, Konstantinos K. \|4 aut
700	1		\|a Kretsavos, Nikolaos \|4 aut
700	1		\|a Theodoratou, Evropi \|4 aut
700	1		\|a Gill, Dipender \|4 aut
700	1		\|a Ioannidis, John PA \|4 aut
700	1		\|a Tzoulaki, Ioanna \|0 (orcid)0000-0002-4275-9328 \|4 aut
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773	1	8	\|g volume:36 \|g year:2020 \|g number:1 \|g day:25 \|g month:09 \|g pages:11-36
856	4	0	\|u https://dx.doi.org/10.1007/s10654-020-00681-w \|z kostenfrei \|3 Volltext
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Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

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