Details der Publikation - Pharmacokinetic Studies of Multiple Active Components in Rat Plasma Using LC-MS/MS after Oral Administration of Shaoyao-Gancao-Fuzi Decoction

Pharmacokinetic Studies of Multiple Active Components in Rat Plasma Using LC-MS/MS after Oral Administration of Shaoyao-Gancao-Fuzi Decoction

Abstract Shaoyao-Gancao-Fuzi decoction, a famous traditional Chinese medicine prescription and composed of the roots of Paeonia lactiflora Pall., Paeoniaceae, Glycyrrhiza glabra L., Fabaceae, and Aconitum carmichaelii Debx., Ranunculaceae, exhibits an anti-inflammatory and analgesic effects. However, pharmacokinetic studies of its potential active ingredients have rarely been studied. The aim of present study was to characterize the pharmacokinetic properties of albiflorin, paeoniflorin, benzoylmesaconine, liquiritin, liquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid after administration of the Shaoyao-Gancao-Fuzi decoction in rat. The plasma concentrations of the seven active components were analyzed by liquid chromatography coupled to mass spectrometry with a good accuracy (87.62–109.71%), precision (2.96–11.38%), extract recovery (85.79–103.68%), matrix effect (90.38–107.77%), and stability (86.66–112.75%). As results, albiflorin, paeoniflorin, and benzoylmesaconine were rapidly absorbed with Tmax < 1 h and slowly eliminated with mean half-life of 6.22–7.11 h. Glycyrrhetinic acid exhibited a high bioavailability. Graphical abstract.

Medienart:	E-Artikel

Erscheinungsjahr:	2020
Erschienen:	2020

Enthalten in:	Zur Gesamtaufnahme - volume:30
Enthalten in:	Revista Brasileira de farmacognosia - 30(2020), 6 vom: Dez., Seite 810-817

Sprache:	Englisch

Beteiligte Personen:	Lin, Li [VerfasserIn] Wang, Yuan [VerfasserIn] Shao, Sennan [VerfasserIn] Lin, Wen [VerfasserIn] Huang, Dan [VerfasserIn] Pan, Ronghua [VerfasserIn] Xia, Yufeng [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Benzoylmesaconine Glycyrrhetinic acid LC-MS/MS Paeoniflorin Pharmacokinetics

Anmerkungen:	© Sociedade Brasileira de Farmacognosia 2021

doi:	10.1007/s43450-020-00119-0

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2122981407

Internformat


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520			\|a Abstract Shaoyao-Gancao-Fuzi decoction, a famous traditional Chinese medicine prescription and composed of the roots of Paeonia lactiflora Pall., Paeoniaceae, Glycyrrhiza glabra L., Fabaceae, and Aconitum carmichaelii Debx., Ranunculaceae, exhibits an anti-inflammatory and analgesic effects. However, pharmacokinetic studies of its potential active ingredients have rarely been studied. The aim of present study was to characterize the pharmacokinetic properties of albiflorin, paeoniflorin, benzoylmesaconine, liquiritin, liquiritigenin, glycyrrhizic acid, and glycyrrhetinic acid after administration of the Shaoyao-Gancao-Fuzi decoction in rat. The plasma concentrations of the seven active components were analyzed by liquid chromatography coupled to mass spectrometry with a good accuracy (87.62–109.71%), precision (2.96–11.38%), extract recovery (85.79–103.68%), matrix effect (90.38–107.77%), and stability (86.66–112.75%). As results, albiflorin, paeoniflorin, and benzoylmesaconine were rapidly absorbed with Tmax < 1 h and slowly eliminated with mean half-life of 6.22–7.11 h. Glycyrrhetinic acid exhibited a high bioavailability. Graphical abstract
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Pharmacokinetic Studies of Multiple Active Components in Rat Plasma Using LC-MS/MS after Oral Administration of Shaoyao-Gancao-Fuzi Decoction

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