Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy

Abstract Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, $ PaO_{2} $/$ FiO_{2} $ < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome..

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:15

Enthalten in:

Internal and emergency medicine - 15(2020), 8 vom: 10. Juli, Seite 1399-1407

Sprache:

Englisch

Beteiligte Personen:

Lenti, Marco Vincenzo [VerfasserIn]
Borrelli de Andreis, Federica [VerfasserIn]
Pellegrino, Ivan [VerfasserIn]
Klersy, Catherine [VerfasserIn]
Merli, Stefania [VerfasserIn]
Miceli, Emanuela [VerfasserIn]
Aronico, Nicola [VerfasserIn]
Mengoli, Caterina [VerfasserIn]
Di Stefano, Michele [VerfasserIn]
Cococcia, Sara [VerfasserIn]
Santacroce, Giovanni [VerfasserIn]
Soriano, Simone [VerfasserIn]
Melazzini, Federica [VerfasserIn]
Delliponti, Mariangela [VerfasserIn]
Baldanti, Fausto [VerfasserIn]
Triarico, Antonio [VerfasserIn]
Corazza, Gino Roberto [VerfasserIn]
Pinzani, Massimo [VerfasserIn]
Di Sabatino, Antonio [VerfasserIn]

Links:

Volltext [kostenfrei]

BKL:

44.80$jUnfallmedizin$jNotfallmedizin

Themen:

Acute respiratory failure
Coronavirus
Hepatitis
Severe acute respiratory syndrome

Anmerkungen:

© The Author(s) 2020

doi:

10.1007/s11739-020-02425-w

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2120824444

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