A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals
Abstract While the COVID-19 pandemic has spurred intense research and collaborative discovery worldwide, the development of a safe, effective, and targeted antiviral from the ground up is time intensive. Therefore, most antiviral discovery efforts are focused on the re-purposing of clinical stage or approved drugs. While emerging data on drugs undergoing COVID-19 repurpose are intriguing, there is an undeniable need to develop broad-spectrum antivirals to prevent future viral pandemics of unknown origin. The ideal drug to curtail rapid viral spread would be a broad-acting agent with activity against a wide range of viruses. Such a drug would work by modulating host-proteins that are often shared by multiple virus families thereby enabling preemptive drug development and therefore rapid deployment at the onset of an outbreak. Targeting host-pathways and cellular proteins that are hijacked by viruses can potentially offer broad-spectrum targets for the development of future antiviral drugs. Such host-directed antivirals are also likely to offer a higher barrier to the development and selection of drug resistant mutations. Given that most approved antivirals do not target host-proteins, we reinforce the need for the development of such antivirals that can be used in pre- and post-exposure populations..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Journal of translational medicine - 18(2020), 1 vom: 15. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chitalia, Vipul C. [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
© The Author(s) 2020 |
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| doi: |
10.1186/s12967-020-02476-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract While the COVID-19 pandemic has spurred intense research and collaborative discovery worldwide, the development of a safe, effective, and targeted antiviral from the ground up is time intensive. Therefore, most antiviral discovery efforts are focused on the re-purposing of clinical stage or approved drugs. While emerging data on drugs undergoing COVID-19 repurpose are intriguing, there is an undeniable need to develop broad-spectrum antivirals to prevent future viral pandemics of unknown origin. The ideal drug to curtail rapid viral spread would be a broad-acting agent with activity against a wide range of viruses. Such a drug would work by modulating host-proteins that are often shared by multiple virus families thereby enabling preemptive drug development and therefore rapid deployment at the onset of an outbreak. Targeting host-pathways and cellular proteins that are hijacked by viruses can potentially offer broad-spectrum targets for the development of future antiviral drugs. Such host-directed antivirals are also likely to offer a higher barrier to the development and selection of drug resistant mutations. Given that most approved antivirals do not target host-proteins, we reinforce the need for the development of such antivirals that can be used in pre- and post-exposure populations. | ||
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Broad-spectrum antivirals | |
| 650 | 4 | |a Mechanism of action (MOA) | |
| 650 | 4 | |a Pandemics | |
| 650 | 4 | |a Drug discovery and development | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Host-directed antivirals | |
| 650 | 4 | |a Antiviral drug design | |
| 650 | 4 | |a Coronavirus (CoV) | |
| 650 | 4 | |a Drug design strategies | |
| 650 | 4 | |a Prophylactic antiviral therapy | |
| 700 | 1 | |a Munawar, Ali H. |0 (orcid)0000-0001-9617-9460 |4 aut | |
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