Diagnostic cut-offs, prevalence, and biochemical predictors of sarcopenia in healthy Indian adults: The Sarcopenia-Chandigarh Urban Bone Epidemiological Study (Sarco-CUBES)

Aim To determine the diagnostic cut-offs and the prevalence of sarcopenia in India. Findings Indians have lower muscle strength and muscle mass than Caucasians. The prevalence of ‘probable sarcopenia’, ‘sarcopenia’, and ‘severe sarcopenia’ is 14.6%, 3.2%, and 2.3%, respectively; corresponding values are higher using well-established Western cut-offs. Message Indigenous and not Western cut-offs should be used to define sarcopenia in Indians..

Purpose Comprehensive data on diagnosis and prevalence of sarcopenia in India are lacking. The present study was undertaken to determine cut-offs for low muscle strength (MS) and low muscle mass (MM), and find out the prevalence of sarcopenia in Indians. Methods Apparently healthy individuals aged ≥ 20 years with no prior history of any co-morbidities were recruited from community by door-to-door survey. Participants eligible for study underwent blood sampling. Individuals identified as having biochemical abnormalities that could potentially affect MS and MM were excluded. Enrolled participants underwent DEXA. Muscle mass, MS, and physical performance were expressed as appendicular skeletal muscle index (ASMI), dominant handgrip strength (HGS), and usual gait speed (GS), respectively. Cut-offs for low MS and MM were defined as HGS and ASMI 2SD < mean of young reference population (20–39 years). A GS ≤ 0.8 m/s defined poor physical performance. Using them, the prevalence of sarcopenia was estimated as per EWGSOP2 recommendations. Results After exclusion, 804 participants were enrolled (mean age = 44.4 years). Peak HGS, ASMI, and GS were achieved in the 3rd/4th decades. Muscle strength/mass was lower than Caucasians. A HGS < 27.5 kg (males)/18.0 kg (females) and an ASMI < 6.11 kg/$ m^{2} $ (males)/4.61 kg/$ m^{2} $ (females) defined low MS and MM, respectively. Accordingly, prevalence of ‘probable sarcopenia’, ‘sarcopenia’, and ‘severe sarcopenia’ was 14.6%, 3.2%, and 2.3%, respectively. Corresponding values were higher when European cut-offs were used. Only serum testosterone positively predicted HGS/ASMI/GS in males. Conclusions Indians have low MS/MM, and hence, indigenous and not Western cut-offs should be used to define sarcopenia in Indians..

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

European geriatric medicine - 11(2020), 5 vom: 05. Juni, Seite 725-736

Sprache:

Englisch

Beteiligte Personen:

Pal, Rimesh [VerfasserIn]
Aggarwal, Anshita [VerfasserIn]
Singh, Tulika [VerfasserIn]
Sharma, Sadhna [VerfasserIn]
Khandelwal, Niranjan [VerfasserIn]
Garg, Abhilasha [VerfasserIn]
Bhansali, Anil [VerfasserIn]
Kumar, Ashok [VerfasserIn]
Yadav, Urmila [VerfasserIn]
Singh, Priyanka [VerfasserIn]
Dhiman, Vandana [VerfasserIn]
Dutta, Pinaki [VerfasserIn]
Bhadada, Sanjay K. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.68 / Gerontologie / Geriatrie / Gerontologie / Geriatrie

Themen:

Gait speed
India
Muscle mass
Muscle strength
Sarcopenia

Anmerkungen:

© European Geriatric Medicine Society 2020

doi:

10.1007/s41999-020-00332-z

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2120003769

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