Details der Publikation - Synthesis and Anticonvulsant Activity of New 2-(4-Oxo-2-Thioxo-1,4-Dihydro-3(2h)-Quinazolinyl)Acetamides

Synthesis and Anticonvulsant Activity of New 2-(4-Oxo-2-Thioxo-1,4-Dihydro-3(2h)-Quinazolinyl)Acetamides

A search for new anticonvulsants led to a series of 2-(4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)- acetamides that were synthesized by reacting (4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)acetic acid with the appropriate amines in the presence of N,N′-carbonyldiimidazole. The tested compounds showed weak and moderate anticonvulsant effects in a pentylenetetrazole-induced seizure model in mice. Several features of the structure—activity relationships are discussed..

Medienart:	E-Artikel

Erscheinungsjahr:	2020
Erschienen:	2020

Enthalten in:	Zur Gesamtaufnahme - volume:54
Enthalten in:	Pharmaceutical chemistry journal - 54(2020), 1 vom: Apr., Seite 1-6

Sprache:	Englisch

Beteiligte Personen:	Bunyatyan, N. D. [VerfasserIn] Severina, H. I. [VerfasserIn] Mokhamad, El Kayal Wassim [VerfasserIn] Zalevskyi, S. V. [VerfasserIn] Shtrygol’, S. Yu. [VerfasserIn] Shark, Amjad Abu [VerfasserIn] Tsyvunin, V. V. [VerfasserIn] Kompantsev, D. V. [VerfasserIn] Shevchenko, A. M. [VerfasserIn] Kovalenko, S. N. [VerfasserIn] Georgiyants, V. A. [VerfasserIn] Ogay, M. A. [VerfasserIn] Khadzhieva, Z. J. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.40$jPharmazie$jPharmazeutika
Themen:	Acetamides Anticonvulsants Quinazoline Synthesis

Anmerkungen:	© Springer Science+Business Media, LLC, part of Springer Nature 2020

doi:	10.1007/s11094-020-02147-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2117619371

Internformat


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520			\|a A search for new anticonvulsants led to a series of 2-(4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)- acetamides that were synthesized by reacting (4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)acetic acid with the appropriate amines in the presence of N,N′-carbonyldiimidazole. The tested compounds showed weak and moderate anticonvulsant effects in a pentylenetetrazole-induced seizure model in mice. Several features of the structure—activity relationships are discussed.
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Synthesis and Anticonvulsant Activity of New 2-(4-Oxo-2-Thioxo-1,4-Dihydro-3(2h)-Quinazolinyl)Acetamides

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