The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients
Objective This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. Conclusions Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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Enthalten in: |
Inflammation research - 69(2020), 6 vom: 29. März, Seite 599-606 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Yuan, Jing [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
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Anmerkungen: |
© Springer Nature Switzerland AG 2020 |
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doi: |
10.1007/s00011-020-01342-0 |
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funding: |
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PPN (Katalog-ID): |
OLC211754214X |
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520 | |a Objective This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020. Methods The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. Conclusions Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. | ||
650 | 4 | |a COVID-19 | |
650 | 4 | |a Clearance ratio | |
650 | 4 | |a LDH | |
650 | 4 | |a CK | |
700 | 1 | |a Zou, Rougrong |4 aut | |
700 | 1 | |a Zeng, Lijiao |4 aut | |
700 | 1 | |a Kou, Shanglong |4 aut | |
700 | 1 | |a Lan, Jianfeng |4 aut | |
700 | 1 | |a Li, Xiaohe |4 aut | |
700 | 1 | |a Liang, Yanhua |4 aut | |
700 | 1 | |a Ding, Xiaoyan |4 aut | |
700 | 1 | |a Tan, Guoyu |4 aut | |
700 | 1 | |a Tang, Shenghong |4 aut | |
700 | 1 | |a Liu, Lei |4 aut | |
700 | 1 | |a Liu, Yingxia |4 aut | |
700 | 1 | |a Pan, Yanchao |4 aut | |
700 | 1 | |a Wang, Zhaoqin |4 aut | |
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