Details der Publikation - Multilineage potential research of Beijing duck amniotic mesenchymal stem cells

Multilineage potential research of Beijing duck amniotic mesenchymal stem cells

Abstract Amnion, which is usually discarded as medical waste, is considered as abundant sources for mesenchymal stem cells. In human and veterinary medicine, the multipotency of mesenchymal stem cells derived from amnion (AMSCs) together with their plasticity, self-renewal, low immunogenicity and nontumorigenicity characteristics make AMSCs a promising candidate cell for cell-based therapies and tissue engineering. However, up till now, the multipotential characteristics and therapeutic potential of AMSCs on preclinical studies remain uncertain. In this work, we successfully obtained AMSCs from Beijing duck embryos in vitro, and also attempted to detect their biological characteristics. The isolated AMSCs were phenotypically identified, the growth kinetics and karyotype were tested. Also, the cells were positive for MSCs-related markers (CD29, CD71, CD105, CD166, Vimentin and Fibronection), while the expression of CD34 and CD45 were undetectable. Additionally, AMSCs also expressed the pluripotent marker gene OCT4. Particularly, when appropriately induced, AMSCs could be induced to trans-differentiate into adipocytes, osteoblasts, chondrocytes and neurocytes in vitro. Together, these results demonstrated that the isolated AMSCs maintained their stemness and proliferation in vitro, which may be useful for future cell therapy in regenerative medicine..

Medienart:	E-Artikel

Erscheinungsjahr:	2018
Erschienen:	2018

Enthalten in:	Zur Gesamtaufnahme - volume:19
Enthalten in:	Cell and tissue banking - 19(2018), 4 vom: 01. Juni, Seite 519-529

Sprache:	Englisch

Beteiligte Personen:	Ma, Caiyun [VerfasserIn] Wang, Kunfu [VerfasserIn] Ji, Hongda [VerfasserIn] Wang, Hongliang [VerfasserIn] Guo, Liangcai [VerfasserIn] Wang, Zhiyong [VerfasserIn] Ren, Han [VerfasserIn] Wang, Xishuai [VerfasserIn] Guan, Weijun [VerfasserIn]

Links:	Volltext [kostenfrei]

BKL:	44.35$jHistologie$XMedizin
Themen:	Amniotic mesenchymal stem cells Beijing duck Biological characteristics Multiply differentiation

Anmerkungen:	© The Author(s) 2018

doi:	10.1007/s10561-018-9701-6

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2112143549

Internformat


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520			\|a Abstract Amnion, which is usually discarded as medical waste, is considered as abundant sources for mesenchymal stem cells. In human and veterinary medicine, the multipotency of mesenchymal stem cells derived from amnion (AMSCs) together with their plasticity, self-renewal, low immunogenicity and nontumorigenicity characteristics make AMSCs a promising candidate cell for cell-based therapies and tissue engineering. However, up till now, the multipotential characteristics and therapeutic potential of AMSCs on preclinical studies remain uncertain. In this work, we successfully obtained AMSCs from Beijing duck embryos in vitro, and also attempted to detect their biological characteristics. The isolated AMSCs were phenotypically identified, the growth kinetics and karyotype were tested. Also, the cells were positive for MSCs-related markers (CD29, CD71, CD105, CD166, Vimentin and Fibronection), while the expression of CD34 and CD45 were undetectable. Additionally, AMSCs also expressed the pluripotent marker gene OCT4. Particularly, when appropriately induced, AMSCs could be induced to trans-differentiate into adipocytes, osteoblasts, chondrocytes and neurocytes in vitro. Together, these results demonstrated that the isolated AMSCs maintained their stemness and proliferation in vitro, which may be useful for future cell therapy in regenerative medicine.
650		4	\|a Beijing duck
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700	1		\|a Guan, Weijun \|4 aut
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Multilineage potential research of Beijing duck amniotic mesenchymal stem cells

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