Details der Publikation - Clinical features, risk factors, and outcomes of patients with interstitial pneumonia with autoimmune features: a population-based study

Clinical features, risk factors, and outcomes of patients with interstitial pneumonia with autoimmune features: a population-based study

Abstract To investigate the clinical features, risk factors and outcomes of patients with interstitial pneumonia with autoimmune features (IPAF). A total of 1429 patients with idiopathic interstitial pneumonia (IIP) and undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD) were screened to identify patients who met IPAF criteria. Clinical, serological, and morphological features of patients with IPAF were characterized. Outcomes between patients with IPAF, UCTD-ILD, and IIP who were divided into idiopathic pulmonary fibrosis (IPF) and non-IPF groups were compared using survival as an endpoint. Patients with IPAF were much common in young female and had lower percentage of ever smoking and a significantly shorter survival than those with non-IPAF (P < 0.001). Subgroup analysis revealed that IPAF cohort survival was worse than that in non-IPF (P < 0.001), but better than that in IPF (P < 0.001). In IPAF cohort, the most common systemic symptom and serological abnormality were Raynaud’s phenomenon (12.9%) and ANA ≥ 1:320 (49.2%); the most frequent high-resolution computed tomography (HRCT) pattern was nonspecific interstitial pneumonia (NSIP) (61.6%). Multivariate analysis indicated that several factors including age, smoking history, organizing pneumonia (OP) pattern in HRCT, and anti-RNP positivity were independently associated with significantly worse survival. IPAF had the distinct clinical features and outcomes compared with other groups of ILD. Additional studies should be needed to explore the underlying autoimmune mechanism and to determine risk stratification in future clinical research..

Medienart:	E-Artikel

Erscheinungsjahr:	2018
Erschienen:	2018

Enthalten in:	Zur Gesamtaufnahme - volume:37
Enthalten in:	Clinical rheumatology - 37(2018), 8 vom: 18. Apr., Seite 2125-2132

Sprache:	Englisch

Beteiligte Personen:	Dai, Jinghong [VerfasserIn] Wang, Lei [VerfasserIn] Yan, Xin [VerfasserIn] Li, Hui [VerfasserIn] Zhou, Kefeng [VerfasserIn] He, Jian [VerfasserIn] Meng, Fanqing [VerfasserIn] Xu, Siyi [VerfasserIn] Liang, Geyu [VerfasserIn] Cai, Hourong [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.00$jMedizin: Allgemeines 44.83$jRheumatologie$jOrthopädie
Themen:	Idiopathic interstitial pneumonia Interstitial pneumonia with autoimmune features Outcome Risk factor Undifferentiated connective tissue disease

Anmerkungen:	© International League of Associations for Rheumatology (ILAR) 2018

doi:	10.1007/s10067-018-4111-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2109248726

Internformat


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520			\|a Abstract To investigate the clinical features, risk factors and outcomes of patients with interstitial pneumonia with autoimmune features (IPAF). A total of 1429 patients with idiopathic interstitial pneumonia (IIP) and undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD) were screened to identify patients who met IPAF criteria. Clinical, serological, and morphological features of patients with IPAF were characterized. Outcomes between patients with IPAF, UCTD-ILD, and IIP who were divided into idiopathic pulmonary fibrosis (IPF) and non-IPF groups were compared using survival as an endpoint. Patients with IPAF were much common in young female and had lower percentage of ever smoking and a significantly shorter survival than those with non-IPAF (P < 0.001). Subgroup analysis revealed that IPAF cohort survival was worse than that in non-IPF (P < 0.001), but better than that in IPF (P < 0.001). In IPAF cohort, the most common systemic symptom and serological abnormality were Raynaud’s phenomenon (12.9%) and ANA ≥ 1:320 (49.2%); the most frequent high-resolution computed tomography (HRCT) pattern was nonspecific interstitial pneumonia (NSIP) (61.6%). Multivariate analysis indicated that several factors including age, smoking history, organizing pneumonia (OP) pattern in HRCT, and anti-RNP positivity were independently associated with significantly worse survival. IPAF had the distinct clinical features and outcomes compared with other groups of ILD. Additional studies should be needed to explore the underlying autoimmune mechanism and to determine risk stratification in future clinical research.
650		4	\|a Idiopathic interstitial pneumonia
650		4	\|a Interstitial pneumonia with autoimmune features
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650		4	\|a Undifferentiated connective tissue disease
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700	1		\|a Cai, Hourong \|4 aut
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Clinical features, risk factors, and outcomes of patients with interstitial pneumonia with autoimmune features: a population-based study

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