Details der Publikation - Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options

Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options

Abstract Multicentric reticulohistiocytosis (MRH) is a rare systemic and devastating disease with main involvement of skin and joints, frequently related with malignancies. Macrophages and TNFα are the main targets of multiple treatment options with variable results. Although MRH has the tendency of self-resolve in an average of 8 years, treatment must be started early to avoid sequelae, mainly in joints with severe deformities and daily life activity impairment. We describe a 50-year-old man with skin and joint involvement, with a non-previously described muscle affectation, that failed to different drugs and achieved skin improvement with infliximab. We review for the first time in medical literature the available therapeutic options of MRH and its outcomes and propose possible future targets..

Medienart:	E-Artikel

Erscheinungsjahr:	2014
Erschienen:	2014

Enthalten in:	Zur Gesamtaufnahme - volume:35
Enthalten in:	Clinical rheumatology - 35(2014), 2 vom: 15. Apr., Seite 527-534

Sprache:	Englisch

Beteiligte Personen:	Macía-Villa, Cristina C. [VerfasserIn] Zea-Mendoza, Antonio [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.00$jMedizin: Allgemeines 44.83$jRheumatologie$jOrthopädie
Themen:	Evolution Joints Multicentric Muscles Reticulohistiocytosis Skin Therapeutic targets Treatment

Anmerkungen:	© Clinical Rheumatology 2014

doi:	10.1007/s10067-014-2611-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2109237767

Internformat


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520			\|a Abstract Multicentric reticulohistiocytosis (MRH) is a rare systemic and devastating disease with main involvement of skin and joints, frequently related with malignancies. Macrophages and TNFα are the main targets of multiple treatment options with variable results. Although MRH has the tendency of self-resolve in an average of 8 years, treatment must be started early to avoid sequelae, mainly in joints with severe deformities and daily life activity impairment. We describe a 50-year-old man with skin and joint involvement, with a non-previously described muscle affectation, that failed to different drugs and achieved skin improvement with infliximab. We review for the first time in medical literature the available therapeutic options of MRH and its outcomes and propose possible future targets.
650		4	\|a Evolution
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700	1		\|a Zea-Mendoza, Antonio \|4 aut
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Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options

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