Details der Publikation - Hepatitis C virus epidemiology in Central-West Tunisia: a population-based cross-sectional study

Hepatitis C virus epidemiology in Central-West Tunisia: a population-based cross-sectional study

Abstract This study aimed to assess the seroprevalence, viraemia and genotype distribution of hepatitis C virus (HCV) in a region in Central-West Tunisia. A door-to-door cross-sectional study was conducted on a randomly selected sample. A total of 3178 individuals aged 5 to 74 years and members of 935 families were investigated. Seroprevalence of HCV was assessed using ELISA tests. The viral load was determined by real-time RT-PCR, and HCV genotyping was conducted by amplification and sequencing in the NS5b genomic region. The global prevalence of HCV antibodies was 3.32% (95% confidence interval [CI]: 2.72-4.00). It was significantly higher in women: 4.47% vs. 2.16% in men, p = 0.001. Seroprevalence increased with age, and the highest rates were found in the 50- to 59-year-old age group (12.90%, 95% CI: 9.45-16.86), suggesting a cohort effect with very low contribution of intrafamilial transmission. Genotyping showed a predominance of subtype 1b (84.6%), with cocirculation of subtypes 2c (9.6%), 1a (1.9%), 1d (1.9%) and 2k (1.9%), similar to the previously reported genotype distribution in Tunisia and with no genetic clusters specific to the study region. These results indicate a higher endemicity of HCV infection when compared to the previously reported nationwide surveillance data. This study provides valuable data that can contribute to current strategies to eliminate hepatitis C..

Medienart:	E-Artikel

Erscheinungsjahr:	2019
Erschienen:	2019

Enthalten in:	Zur Gesamtaufnahme - volume:164
Enthalten in:	Archives of virology - 164(2019), 9 vom: 10. Juni, Seite 2243-2253

Sprache:	Englisch

Beteiligte Personen:	Bettaieb, Jihene [VerfasserIn] Chouikha, Anissa [VerfasserIn] Khedhiri, Marwa [VerfasserIn] Kharroubi, Ghassen [VerfasserIn] Badreddine, Malek [VerfasserIn] Bel Hadj Hmida, Nabil [VerfasserIn] Gharbi, Adel [VerfasserIn] Hammemi, Walid [VerfasserIn] Sadraoui, Amel [VerfasserIn] Ben Yahia, Ahlem [VerfasserIn] Meddeb, Zina [VerfasserIn] Ben Salah, Afif [VerfasserIn] Triki, Henda [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

RVK:	RVK Klassifikation ELIB24 ELIB09

Anmerkungen:	© Springer-Verlag GmbH Austria, part of Springer Nature 2019

doi:	10.1007/s00705-019-04308-8

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2108041583

Internformat


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520			\|a Abstract This study aimed to assess the seroprevalence, viraemia and genotype distribution of hepatitis C virus (HCV) in a region in Central-West Tunisia. A door-to-door cross-sectional study was conducted on a randomly selected sample. A total of 3178 individuals aged 5 to 74 years and members of 935 families were investigated. Seroprevalence of HCV was assessed using ELISA tests. The viral load was determined by real-time RT-PCR, and HCV genotyping was conducted by amplification and sequencing in the NS5b genomic region. The global prevalence of HCV antibodies was 3.32% (95% confidence interval [CI]: 2.72-4.00). It was significantly higher in women: 4.47% vs. 2.16% in men, p = 0.001. Seroprevalence increased with age, and the highest rates were found in the 50- to 59-year-old age group (12.90%, 95% CI: 9.45-16.86), suggesting a cohort effect with very low contribution of intrafamilial transmission. Genotyping showed a predominance of subtype 1b (84.6%), with cocirculation of subtypes 2c (9.6%), 1a (1.9%), 1d (1.9%) and 2k (1.9%), similar to the previously reported genotype distribution in Tunisia and with no genetic clusters specific to the study region. These results indicate a higher endemicity of HCV infection when compared to the previously reported nationwide surveillance data. This study provides valuable data that can contribute to current strategies to eliminate hepatitis C.
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Hepatitis C virus epidemiology in Central-West Tunisia: a population-based cross-sectional study

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