Details der Publikation - Fine-mapping the putative chromosome 17q21–22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis

Fine-mapping the putative chromosome 17q21–22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis

Abstract Prostate cancer linkage studies have suggested the existence of a prostate cancer susceptibility gene on chromosome 17q21–22. We now report the results of an extended linkage analysis including 95 new multiplex prostate cancer families and 9 additional microsatellite markers resulting in a maximum LOD score of 2.99 at approximately 81–82 cM for all 453 pedigrees. Results from these 95 new pedigrees provide additional support for a chromosome 17q21–22 prostate cancer susceptibility gene. Inclusion of the 9 additional markers significantly reduced the size of the candidate region, as defined using a 1-LOD support interval, especially when focusing analyses on subsets of pedigrees with four or more confirmed affecteds or average age of diagnosis less than or equal to 65 years. A novel subset analysis of only those families (n = 147) that had four or more prostate cancer cases and an average age of prostate cancer diagnosis ≤ 65 years results in a maximum LOD score of 5.49 at 78 cM with a 1-LOD support interval of 10 cM. This large set of pedigrees with four more prostate cancer cases characterized by early-onset disease will serve as a useful resource for identifying the putative 17q21–22 prostate cancer susceptibility gene..

Medienart:	E-Artikel

Erscheinungsjahr:	2006
Erschienen:	2006

Enthalten in:	Zur Gesamtaufnahme - volume:121
Enthalten in:	Human genetics - 121(2006), 1 vom: 21. Nov., Seite 49-55

Sprache:	Englisch

Beteiligte Personen:	Lange, Ethan M. [VerfasserIn] Robbins, Christiane M. [VerfasserIn] Gillanders, Elizabeth M. [VerfasserIn] Zheng, Siqun Lilly [VerfasserIn] Xu, Jianfeng [VerfasserIn] Wang, Yunfei [VerfasserIn] White, Kirsten A. [VerfasserIn] Chang, Bao-Li [VerfasserIn] Ho, Lindsey A. [VerfasserIn] Trent, Jeffrey M. [VerfasserIn] Carpten, John D. [VerfasserIn] Isaacs, William B. [VerfasserIn] Cooney, Kathleen A. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Early onset Linkage analysis Prostate cancer Subset analyses

Anmerkungen:	© Springer-Verlag 2006

doi:	10.1007/s00439-006-0274-2

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2106429541

Internformat


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100	1		\|a Lange, Ethan M. \|e verfasserin \|4 aut
245	1	0	\|a Fine-mapping the putative chromosome 17q21–22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis
264		1	\|c 2006
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520			\|a Abstract Prostate cancer linkage studies have suggested the existence of a prostate cancer susceptibility gene on chromosome 17q21–22. We now report the results of an extended linkage analysis including 95 new multiplex prostate cancer families and 9 additional microsatellite markers resulting in a maximum LOD score of 2.99 at approximately 81–82 cM for all 453 pedigrees. Results from these 95 new pedigrees provide additional support for a chromosome 17q21–22 prostate cancer susceptibility gene. Inclusion of the 9 additional markers significantly reduced the size of the candidate region, as defined using a 1-LOD support interval, especially when focusing analyses on subsets of pedigrees with four or more confirmed affecteds or average age of diagnosis less than or equal to 65 years. A novel subset analysis of only those families (n = 147) that had four or more prostate cancer cases and an average age of prostate cancer diagnosis ≤ 65 years results in a maximum LOD score of 5.49 at 78 cM with a 1-LOD support interval of 10 cM. This large set of pedigrees with four more prostate cancer cases characterized by early-onset disease will serve as a useful resource for identifying the putative 17q21–22 prostate cancer susceptibility gene.
650		4	\|a Prostate cancer
650		4	\|a Linkage analysis
650		4	\|a Early onset
650		4	\|a Subset analyses
700	1		\|a Robbins, Christiane M. \|4 aut
700	1		\|a Gillanders, Elizabeth M. \|4 aut
700	1		\|a Zheng, Siqun Lilly \|4 aut
700	1		\|a Xu, Jianfeng \|4 aut
700	1		\|a Wang, Yunfei \|4 aut
700	1		\|a White, Kirsten A. \|4 aut
700	1		\|a Chang, Bao-Li \|4 aut
700	1		\|a Ho, Lindsey A. \|4 aut
700	1		\|a Trent, Jeffrey M. \|4 aut
700	1		\|a Carpten, John D. \|4 aut
700	1		\|a Isaacs, William B. \|4 aut
700	1		\|a Cooney, Kathleen A. \|4 aut
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773	1	8	\|g volume:121 \|g year:2006 \|g number:1 \|g day:21 \|g month:11 \|g pages:49-55
856	4	0	\|u https://dx.doi.org/10.1007/s00439-006-0274-2 \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_150
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912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_267
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
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912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2020
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912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2134
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2433
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2474
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 121 \|j 2006 \|e 1 \|b 21 \|c 11 \|h 49-55

Fine-mapping the putative chromosome 17q21–22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis

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