Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer
Purpose To determine which indicators, anatomical nodal metastasis (Japan Pancreas Society, JPS), number of positive lymph nodes (PLN), or lymph node ratio (LNR), is the best means of assessing lymph node involvement in pancreatic cancer. Methods This retrospective study analyzed 275 patients with pancreatic cancer treated at a single institution. Survival curves according to the JPS, PLN, or LNR were assessed by the Kaplan–Meier method. Prognostic value of each classification was explored by Cox regression analysis after adjustments for clinical factors. Results Multivariate analysis showed that, relative to n0 in the JPS, hazard ratios (HR) in n1, n2, and n3 were 1.72, 1.73, and 2.75, respectively, with no difference in survival between n1 and n2. Relative to PLN of 0, the HR in the PLN categories of 1∼2, 3, and >3 were 1.39, 1.65, and 3.03, respectively. Relative to LNR of 0, the HR in the categories of 0 < LNR ≤ 0.1, 0.1 < LNR ≤ 0.2, and LNR > 0.2 were 1.27, 2.00, and 5.58, respectively. An incremental increase in the HR was observed as the LNR category progressed, and differences between the survivals were distinct when stratified by the LNR. Conclusions The LNR was an accurate predictor of survival among three assessment strategies and could be proposed as a candidate for use as N categories, pending validation studies..
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:401 |
|---|---|
| Enthalten in: |
Langenbeck's archives of surgery - 401(2016), 8 vom: 05. Apr., Seite 1143-1152 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yamada, Suguru [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Lymph node metastasis |
|---|
| RVK: |
|---|
| Anmerkungen: |
© Springer-Verlag Berlin Heidelberg 2016 |
|---|
| doi: |
10.1007/s00423-016-1412-5 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
OLC2105933033 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | OLC2105933033 | ||
| 003 | DE-627 | ||
| 005 | 20230403022709.0 | ||
| 007 | tu | ||
| 008 | 230403s2016 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00423-016-1412-5 |2 doi | |
| 035 | |a (DE-627)OLC2105933033 | ||
| 035 | |a (DE-He213)s00423-016-1412-5-p | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q VZ |
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a XA 26500 |q VZ |2 rvk | ||
| 100 | 1 | |a Yamada, Suguru |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a © Springer-Verlag Berlin Heidelberg 2016 | ||
| 520 | |a Purpose To determine which indicators, anatomical nodal metastasis (Japan Pancreas Society, JPS), number of positive lymph nodes (PLN), or lymph node ratio (LNR), is the best means of assessing lymph node involvement in pancreatic cancer. Methods This retrospective study analyzed 275 patients with pancreatic cancer treated at a single institution. Survival curves according to the JPS, PLN, or LNR were assessed by the Kaplan–Meier method. Prognostic value of each classification was explored by Cox regression analysis after adjustments for clinical factors. Results Multivariate analysis showed that, relative to n0 in the JPS, hazard ratios (HR) in n1, n2, and n3 were 1.72, 1.73, and 2.75, respectively, with no difference in survival between n1 and n2. Relative to PLN of 0, the HR in the PLN categories of 1∼2, 3, and >3 were 1.39, 1.65, and 3.03, respectively. Relative to LNR of 0, the HR in the categories of 0 < LNR ≤ 0.1, 0.1 < LNR ≤ 0.2, and LNR > 0.2 were 1.27, 2.00, and 5.58, respectively. An incremental increase in the HR was observed as the LNR category progressed, and differences between the survivals were distinct when stratified by the LNR. Conclusions The LNR was an accurate predictor of survival among three assessment strategies and could be proposed as a candidate for use as N categories, pending validation studies. | ||
| 650 | 4 | |a Pancreatic cancer | |
| 650 | 4 | |a Lymph node metastasis | |
| 650 | 4 | |a Lymph node ratio | |
| 650 | 4 | |a Prognosis | |
| 700 | 1 | |a Fujii, Tsutomu |4 aut | |
| 700 | 1 | |a Hirakawa, Akihiro |4 aut | |
| 700 | 1 | |a Kanda, Mitsuro |4 aut | |
| 700 | 1 | |a Sugimoto, Hiroyuki |4 aut | |
| 700 | 1 | |a Kodera, Yasuhiro |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Langenbeck's archives of surgery |d Springer Berlin Heidelberg, 1998 |g 401(2016), 8 vom: 05. Apr., Seite 1143-1152 |w (DE-627)242897045 |w (DE-600)1423681-3 |w (DE-576)06540520X |x 1435-2443 |7 nnns |
| 773 | 1 | 8 | |g volume:401 |g year:2016 |g number:8 |g day:05 |g month:04 |g pages:1143-1152 |
| 856 | 4 | 1 | |u https://doi.org/10.1007/s00423-016-1412-5 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a GBV_ILN_267 | ||
| 912 | |a GBV_ILN_2018 | ||
| 912 | |a GBV_ILN_2339 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4219 | ||
| 912 | |a GBV_ILN_4277 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 936 | r | v | |a XA 26500 |
| 951 | |a AR | ||
| 952 | |d 401 |j 2016 |e 8 |b 05 |c 04 |h 1143-1152 | ||