Details der Publikation - Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

Purpose To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. Methods Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. Results Eotaxin-1 concentration in tears of SAC patients [2,100±503 (SEM) pg/ml] and normal subjects (1,193±176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). Conclusions The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy..

Medienart:	E-Artikel

Erscheinungsjahr:	2004
Erschienen:	2004

Enthalten in:	Zur Gesamtaufnahme - volume:242
Enthalten in:	Graefe's archive for clinical and experimental ophthalmology - 242(2004), 11 vom: 25. Juni, Seite 966-970

Sprache:	Englisch

Beteiligte Personen:	Eperon, Simone [VerfasserIn] Sauty, Alain [VerfasserIn] Lanz, René [VerfasserIn] Leimgruber, Annette [VerfasserIn] Lurati, Floriana [VerfasserIn] Guex-Crosier, Yan [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Allergic Patient Grass Pollen Ocular Allergy Pollen Season Tree Pollen

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© Springer-Verlag 2004

doi:	10.1007/s00417-004-0943-6

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2105493033

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520			\|a Purpose To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. Methods Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. Results Eotaxin-1 concentration in tears of SAC patients [2,100±503 (SEM) pg/ml] and normal subjects (1,193±176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). Conclusions The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.
650		4	\|a Pollen Season
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Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

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