Details der Publikation - Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population

Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population

Purpose Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will contribute to further understanding the pathogenesis of the disease, thus allowing the development of appropriate targeted treatments. Recently, the link between cancer and inflammation has become more evident and inflammation has been proposed as the seventh hallmark of cancer. Previous studies have suggested that key cytokines involved in inflammation may have an important role in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammation-related genes: IL-6, IL6-R, and IL6-ST, influence lung cancer risk in Moroccan population. Materials and Methods Single nucleotide polymorphisms (SNPs) in IL-6, IL6-R, and IL6-ST genes were assessed in 120 controls and 120 patients with confirmed lung cancer diagnosis. Genotyping analysis was performed with the TaqMan® allelic discrimination technology. The results were analyzed using SPSS 24.0 software. Results Among the studied SNPs, we found a significant association for the IL-6 (rs2069840) (OR = 1.63; 95% confidence interval 1.08–2.47; p = 0.01). No significant association was observed for the remaining SNPs of IL-6R (rs2228145) and IL-6ST (rs2228044) genes. Conclusion Our results suggest the IL-6 (rs2069840) polymorphism may influence the occurrence of lung cancer in Moroccan patients..

Medienart:	E-Artikel

Erscheinungsjahr:	2019
Erschienen:	2019

Enthalten in:	Zur Gesamtaufnahme - volume:197
Enthalten in:	Lung - 197(2019), 5 vom: 29. Aug., Seite 601-608

Sprache:	Englisch

Beteiligte Personen:	Kaanane, Houda [VerfasserIn] Senhaji, Nezha [VerfasserIn] Berradi, Hind [VerfasserIn] Benchakroun, Nadia [VerfasserIn] Benider, Abdellatif [VerfasserIn] Karkouri, Mehdi [VerfasserIn] El Attar, Hicham [VerfasserIn] Khyatti, Meriem [VerfasserIn] Nadifi, Sellama [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.84$jPulmologie
Themen:	Cytokines Inflammation Lung cancer Moroccan population Polymorphisms Risk

Anmerkungen:	© Springer Science+Business Media, LLC, part of Springer Nature 2019

doi:	10.1007/s00408-019-00261-0

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2105374506

Internformat


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520			\|a Purpose Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will contribute to further understanding the pathogenesis of the disease, thus allowing the development of appropriate targeted treatments. Recently, the link between cancer and inflammation has become more evident and inflammation has been proposed as the seventh hallmark of cancer. Previous studies have suggested that key cytokines involved in inflammation may have an important role in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammation-related genes: IL-6, IL6-R, and IL6-ST, influence lung cancer risk in Moroccan population. Materials and Methods Single nucleotide polymorphisms (SNPs) in IL-6, IL6-R, and IL6-ST genes were assessed in 120 controls and 120 patients with confirmed lung cancer diagnosis. Genotyping analysis was performed with the TaqMan® allelic discrimination technology. The results were analyzed using SPSS 24.0 software. Results Among the studied SNPs, we found a significant association for the IL-6 (rs2069840) (OR = 1.63; 95% confidence interval 1.08–2.47; p = 0.01). No significant association was observed for the remaining SNPs of IL-6R (rs2228145) and IL-6ST (rs2228044) genes. Conclusion Our results suggest the IL-6 (rs2069840) polymorphism may influence the occurrence of lung cancer in Moroccan patients.
650		4	\|a Lung cancer
650		4	\|a Inflammation
650		4	\|a Cytokines
650		4	\|a Polymorphisms
650		4	\|a Risk
650		4	\|a Moroccan population
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700	1		\|a Khyatti, Meriem \|4 aut
700	1		\|a Nadifi, Sellama \|4 aut
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Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population

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