Details der Publikation - Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility

Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility

Background Preeclampsia (PE) is one of the main causes of death among the pregnant women as well as newborns. Although the etiological cause of preeclampsia is not yet clear, a range of risk factors has been suggested. MicroRNAs (like miRNA-152) are small non-coding molecules that play a role in a wide spectrum of biological processes, such as cell proliferation and angiogenesis. This study aimed to investigate the possible relationship of miRNA-152 rs12940701 polymorphism and the risk of preeclampsia among the pregnant women as compared with the control group. Methods Genotyping of miRNA-152 rs12940701 polymorphism was performed using blood and placenta samples of 223 preeclampsia women and 229 normotensive pregnant women by a polymerase chain reaction-restriction fragment length polymorphism method. Results The results obtained from maternal blood showed an increase in T alleles for PE women, that there was no significant difference between the PE and control group (OR = 1.7, P = 0.19). In addition, no significant difference was found in the TT genotype between the two groups (11.6% vs. 7%, OR = 1.4, P = 0.3). Similarly, the results obtained from placental samples were identical. Conclusions A lack of relationship between the polymorphism of miRNA-152 rs12940701 gene and preeclampsia development has been shown..

Medienart:	E-Artikel

Erscheinungsjahr:	2018
Erschienen:	2018

Enthalten in:	Zur Gesamtaufnahme - volume:299
Enthalten in:	Archives of gynecology and obstetrics - 299(2018), 2 vom: 26. Nov., Seite 475-480

Sprache:	Englisch

Beteiligte Personen:	Rokni, Mohsen [VerfasserIn] Salimi, Saeedeh [VerfasserIn] Sohrabi, Tayebeh [VerfasserIn] Asghari, Somaye [VerfasserIn] Teimoori, Batool [VerfasserIn] Saravani, Mohsen [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.92$jGynäkologie
Themen:	Gene MiRNA-152 Polymorphism Preeclampsia

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© Springer-Verlag GmbH Germany, part of Springer Nature 2018

doi:	10.1007/s00404-018-4979-y

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2105262368

Internformat


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520			\|a Background Preeclampsia (PE) is one of the main causes of death among the pregnant women as well as newborns. Although the etiological cause of preeclampsia is not yet clear, a range of risk factors has been suggested. MicroRNAs (like miRNA-152) are small non-coding molecules that play a role in a wide spectrum of biological processes, such as cell proliferation and angiogenesis. This study aimed to investigate the possible relationship of miRNA-152 rs12940701 polymorphism and the risk of preeclampsia among the pregnant women as compared with the control group. Methods Genotyping of miRNA-152 rs12940701 polymorphism was performed using blood and placenta samples of 223 preeclampsia women and 229 normotensive pregnant women by a polymerase chain reaction-restriction fragment length polymorphism method. Results The results obtained from maternal blood showed an increase in T alleles for PE women, that there was no significant difference between the PE and control group (OR = 1.7, P = 0.19). In addition, no significant difference was found in the TT genotype between the two groups (11.6% vs. 7%, OR = 1.4, P = 0.3). Similarly, the results obtained from placental samples were identical. Conclusions A lack of relationship between the polymorphism of miRNA-152 rs12940701 gene and preeclampsia development has been shown.
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Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility

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