Details der Publikation - Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature

Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature

Abstract We describe a 25-year-old male patient with primary diffuse leptomeningeal gliomatosis (PDLG) presenting with gait ataxia, positive Lhermitte’s sign, double vision, and right abducens nerve palsy. Spinal magnetic resonance imaging showed extended intradural, extramedullary, contrast-enhancing masses with compression of the myelon. Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I. Despite chemotherapy with vincristin and carboplatin, the patient died 2 months after admission. A thorough autopsy showed no evidence for primary neoplasms in brain, spine and optic nerve. Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development. To our knowledge, this is the first definitive case of pilocytic astrocytoma presenting as PDLG..

Medienart:	E-Artikel

Erscheinungsjahr:	2005
Erschienen:	2005

Enthalten in:	Zur Gesamtaufnahme - volume:110
Enthalten in:	Acta neuropathologica - 110(2005), 3 vom: 08. Juli, Seite 306-311

Sprache:	Englisch

Beteiligte Personen:	Bohner, Georg [VerfasserIn] Masuhr, Florian [VerfasserIn] Distl, Roland [VerfasserIn] Katchanov, Juri [VerfasserIn] Klingebiel, Randolf [VerfasserIn] Zschenderlein, Rolf [VerfasserIn] von Deimling, Andreas [VerfasserIn] van Landeghem, Frank K. H. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Pilocytic astrocytoma Primary diffuse leptomeningeal gliomatosis

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© Springer-Verlag 2005

doi:	10.1007/s00401-005-1051-3

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2105026923

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520			\|a Abstract We describe a 25-year-old male patient with primary diffuse leptomeningeal gliomatosis (PDLG) presenting with gait ataxia, positive Lhermitte’s sign, double vision, and right abducens nerve palsy. Spinal magnetic resonance imaging showed extended intradural, extramedullary, contrast-enhancing masses with compression of the myelon. Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I. Despite chemotherapy with vincristin and carboplatin, the patient died 2 months after admission. A thorough autopsy showed no evidence for primary neoplasms in brain, spine and optic nerve. Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development. To our knowledge, this is the first definitive case of pilocytic astrocytoma presenting as PDLG.
650		4	\|a Pilocytic astrocytoma
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700	1		\|a von Deimling, Andreas \|4 aut
700	1		\|a van Landeghem, Frank K. H. \|4 aut
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Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature

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