Details der Publikation - SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation

SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation

Purpose The consumption of Brazil nuts has been associated with benefits to lipid metabolism and reductions in total cholesterol and LDL concentrations. They are the richest natural source of selenium which has essential functions in human physiology. Genetic polymorphisms in Selenoprotein P could impair lipid and glucose metabolisms. The aim of this work was to verify the influence of polymorphisms in genes for selenoproteins on blood lipid levels after dietary supplementation with Brazil nuts in healthy adults. Methods The study included 130 healthy volunteers selected at the University of São Paulo, Brazil. They were supplemented with one nut a day for 8 weeks, followed by 8 weeks without intervention. The following analyses were performed: anthropometric measurements, serum fasting glucose, lipid profile, C-reactive protein and plasma MDA levels. The volunteers were genotyped for SNPs rs1050450, rs3811699, rs1800699, rs713041, rs3877899, rs7579, rs34713741, and rs5845 in genes for selenoproteins. Results The concentrations of total cholesterol and fasting glucose levels decreased after 8 weeks of supplementation (p < 0.05). Glucose levels were modulated by rs3877899 in SEPP1, with significantly lower levels observed for individuals with the GA + AA genotype (p = 0.025). In addition, rs7579 was associated with cholesterol concentrations, which were significantly lower for individuals with the GG genotype (p = 0.053). Conclusions Supplementation with one Brazil nut a day for 8 weeks reduced total cholesterol and glucose levels. Furthermore, our results suggest that rs3877899 might be associated with glucose concentrations and rs7579 with cholesterol concentrations. Therefore, the effect of genetic variations should be considered in future nutritional interventions evaluating the response to Brazil nut supplementation..

Medienart:	E-Artikel

Erscheinungsjahr:	2017
Erschienen:	2017

Enthalten in:	Zur Gesamtaufnahme - volume:57
Enthalten in:	European journal of nutrition - 57(2017), 5 vom: 13. Mai, Seite 1873-1882

Sprache:	Englisch

Beteiligte Personen:	Donadio, Janaina L. S. [VerfasserIn] Rogero, Marcelo M. [VerfasserIn] Guerra-Shinohara, Elvira M. [VerfasserIn] Desmarchelier, Charles [VerfasserIn] Borel, Patrick [VerfasserIn] Cozzolino, Silvia M. F. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.21$jErnährung$XMedizin
Themen:	Brazil nuts Lipid profile Nutrigenetics Polymorphisms

RVK:	RVK Klassifikation ELIB10 ELIB09 ELIB24

Anmerkungen:	© Springer-Verlag Berlin Heidelberg 2017

doi:	10.1007/s00394-017-1470-7

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2104926831

Internformat


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245	1	0	\|a SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation
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520			\|a Purpose The consumption of Brazil nuts has been associated with benefits to lipid metabolism and reductions in total cholesterol and LDL concentrations. They are the richest natural source of selenium which has essential functions in human physiology. Genetic polymorphisms in Selenoprotein P could impair lipid and glucose metabolisms. The aim of this work was to verify the influence of polymorphisms in genes for selenoproteins on blood lipid levels after dietary supplementation with Brazil nuts in healthy adults. Methods The study included 130 healthy volunteers selected at the University of São Paulo, Brazil. They were supplemented with one nut a day for 8 weeks, followed by 8 weeks without intervention. The following analyses were performed: anthropometric measurements, serum fasting glucose, lipid profile, C-reactive protein and plasma MDA levels. The volunteers were genotyped for SNPs rs1050450, rs3811699, rs1800699, rs713041, rs3877899, rs7579, rs34713741, and rs5845 in genes for selenoproteins. Results The concentrations of total cholesterol and fasting glucose levels decreased after 8 weeks of supplementation (p < 0.05). Glucose levels were modulated by rs3877899 in SEPP1, with significantly lower levels observed for individuals with the GA + AA genotype (p = 0.025). In addition, rs7579 was associated with cholesterol concentrations, which were significantly lower for individuals with the GG genotype (p = 0.053). Conclusions Supplementation with one Brazil nut a day for 8 weeks reduced total cholesterol and glucose levels. Furthermore, our results suggest that rs3877899 might be associated with glucose concentrations and rs7579 with cholesterol concentrations. Therefore, the effect of genetic variations should be considered in future nutritional interventions evaluating the response to Brazil nut supplementation.
650		4	\|a Brazil nuts
650		4	\|a Lipid profile
650		4	\|a Polymorphisms
650		4	\|a Nutrigenetics
700	1		\|a Rogero, Marcelo M. \|4 aut
700	1		\|a Guerra-Shinohara, Elvira M. \|4 aut
700	1		\|a Desmarchelier, Charles \|4 aut
700	1		\|a Borel, Patrick \|4 aut
700	1		\|a Cozzolino, Silvia M. F. \|4 aut
773	0	8	\|i Enthalten in \|t European journal of nutrition \|d Springer Berlin Heidelberg, 1999 \|g 57(2017), 5 vom: 13. Mai, Seite 1873-1882 \|h Online-Ressource \|w (DE-627)254910963 \|w (DE-600)1463312-7 \|w (DE-576)091204844 \|x 1436-6215 \|7 nnns
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SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation

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