Paraoxonase (PON1) polymorphisms Q192R and L55M are not associated with human longevity

Background Genetic mutations in the paraoxonase 1 (PON1) encoding gene have been considered to affect mortality and of these the functional promoter region polymorphisms Q192R and L55M are among the most widely studied. Objective The aim of this study was to determine whether the Q192R and L55M polymorphisms of PON1 can increase susceptibility to longevity. A meta-analysis was performed to obtain a comprehensive estimation of the association between Q192R and L55M and longevity in long-lived individuals (LLIs) aged 80 years or more. Material and methods A search was carried out in the PubMed database (from January 2001 to May 2014) to obtain data on the role of PON1 polymorphisms in longevity and a pooled odds ratio (OR) with a 95 % confidence interval (CI) was used to assess the associations. Results The meta-analysis was based on 9 studies of PON1 Q192R and 5 studies of PON1 L55M that covered a total of 5086 LLIs and 4494 controls. Overall, significantly increased risks were not observed for either Q192R or L55M. The results of the statistical calculations were as follows: R vs. Q (additive model): OR = 1.080, 95 % CI = 0.989–1.179, p = 0.088 and RR + RQ vs. QQ (dominant model): OR = 1.099, 95 % CI = 0.975–1.240, p = 0.124; M vs. L (additive model): OR = 0.946, 95 % CI = 0.862–1.039, p = 0.245 and MM + ML vs. LL (dominant model): OR = 0.951, 95 % CI = 0.836–1.081, p = 0.442 for Q192R and L55M, respectively. The results did not change with an age cut-off among the LLIs of ≥ 93 years. Conclusion No evidence that the Q192R and L55M polymorphisms of PON1 impacted on the probability of reaching extreme ages was found although this cannot be completely ruled out; however, the possibility of population-specific effects due to the influence of and interaction between different genes or environmental factors could not be ruled out..

Medienart:

E-Artikel

Erscheinungsjahr:

2015

Erschienen:

2015

Enthalten in:

Zur Gesamtaufnahme - volume:49

Enthalten in:

Zeitschrift für Gerontologie und Geriatrie - 49(2015), 1 vom: 12. Mai, Seite 24-31

Sprache:

Englisch

Beteiligte Personen:

Wei, Gan-Zhong [VerfasserIn]
Zhu, Mei-Yan [VerfasserIn]
Wang, Fang [VerfasserIn]
Zhao, Yue-Guang [VerfasserIn]
Li, Shan-Shan [VerfasserIn]
Liu, Tong-Yang [VerfasserIn]
Luo, Ying [VerfasserIn]
Tang, Wen-Ru [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Aged, 80 and over
Aging genetics
Alleles
Genotype
Humans

RVK:

RVK Klassifikation

Anmerkungen:

© Springer-Verlag Berlin Heidelberg 2015

doi:

10.1007/s00391-015-0892-1

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2104848792

Zugang & Verfügbarkeit




Zugehörige Publikationen/Bände

    Haven't found what you're looking for?