Details der Publikation - Surgical perspectives regarding application of biomaterials for the management of large congenital diaphragmatic hernia defects

Surgical perspectives regarding application of biomaterials for the management of large congenital diaphragmatic hernia defects

Abstract This review focuses on the surgical viewpoints on patch repairs in neonates with large congenital diaphragmatic hernia defects. The main focus is on the various biomaterials that have been employed to date with regard to their source of origins, degradation properties as well as tissue integration characteristics. Further focus is on the present knowledge on patch integration when biomaterials are placed in the diaphragmatic defect. The review will also look at the present evidence on the biomechanical characteristics of the most commonly used biomaterials and compares these materials to diaphragmatic tissue to offer more insight on the present practice of patch repairs in large defects. Since tissue engineering and regenerative medicine has offered another dimension to diaphragmatic replacement, a detailed overview of this technology will be undertaken with regard to cell sourcing, scaffolds, in vitro versus in vivo implants as well as quality of tissue produced, to explore the limitations and the feasibility facing the scientific community in its clinical implementation of skeletal muscle-engineered tissue beyond laboratory research for diaphragmatic replacement..

Medienart:	E-Artikel

Erscheinungsjahr:	2018
Erschienen:	2018

Enthalten in:	Zur Gesamtaufnahme - volume:34
Enthalten in:	Pediatric surgery international - 34(2018), 5 vom: 02. Apr., Seite 475-489

Sprache:	Englisch

Beteiligte Personen:	Saxena, Amulya K. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Biomaterials Biomechanics Congenital diaphragmatic hernia Patch repair Prosthetic materials Recurrence Tissue engineering

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© Springer-Verlag GmbH Germany, part of Springer Nature 2018

doi:	10.1007/s00383-018-4253-1

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2104793718

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520			\|a Abstract This review focuses on the surgical viewpoints on patch repairs in neonates with large congenital diaphragmatic hernia defects. The main focus is on the various biomaterials that have been employed to date with regard to their source of origins, degradation properties as well as tissue integration characteristics. Further focus is on the present knowledge on patch integration when biomaterials are placed in the diaphragmatic defect. The review will also look at the present evidence on the biomechanical characteristics of the most commonly used biomaterials and compares these materials to diaphragmatic tissue to offer more insight on the present practice of patch repairs in large defects. Since tissue engineering and regenerative medicine has offered another dimension to diaphragmatic replacement, a detailed overview of this technology will be undertaken with regard to cell sourcing, scaffolds, in vitro versus in vivo implants as well as quality of tissue produced, to explore the limitations and the feasibility facing the scientific community in its clinical implementation of skeletal muscle-engineered tissue beyond laboratory research for diaphragmatic replacement.
650		4	\|a Congenital diaphragmatic hernia
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650		4	\|a Recurrence
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650		4	\|a Tissue engineering
650		4	\|a Biomechanics
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Surgical perspectives regarding application of biomaterials for the management of large congenital diaphragmatic hernia defects

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