Details der Publikation - Treatment of Chronic Inflammatory Demyelinating Polyneuropathy

Treatment of Chronic Inflammatory Demyelinating Polyneuropathy

Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is one of the acquired demyelinating neuropathies and is considered to be immune mediated. Diagnosis is typically based on clinical history, neurologic examination, electrophysiologic studies, CSF studies, and pathologic examination. Early diagnosis and treatment is important to prevent irreversible axonal loss and optimize improvement in function. The first-line agents for treatment are intravenous immunoglobulin (IVIg), corticosteroids, and plasmapheresis, which have all been demonstrated to be effective in controlled studies. Studies have not shown a significant difference between these three treatments, and the initial choice of therapy is often based on availability, cost, ease of administration, and side effect profile. If patients do not respond to one of these agents, they may respond to one of the others and sometimes in combination. If the first-line agents are not effective, chemotherapeutic or immunosuppressive agents may be considered. There are limited controlled studies of these modalities, and they are often used in conjunction with a first-line treatment. The majority of patients require long-term therapy to maintain a response and to prevent relapse..

Medienart:	E-Artikel

Erscheinungsjahr:	2015
Erschienen:	2015

Enthalten in:	Zur Gesamtaufnahme - volume:15
Enthalten in:	Current neurology and neuroscience reports - 15(2015), 7 vom: 26. Mai

Sprache:	Englisch

Beteiligte Personen:	Kleyman, Inna [VerfasserIn] Brannagan, Thomas H. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.90$jNeurologie
Themen:	Chronic inflammatory demyelinating polyneuropathy (CIDP) Corticosteroids Intravenous immunoglobulin (IVIg) Plasmapheresis

Anmerkungen:	© Springer Science+Business Media New York 2015

doi:	10.1007/s11910-015-0563-z

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2102989879

Internformat


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520			\|a Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is one of the acquired demyelinating neuropathies and is considered to be immune mediated. Diagnosis is typically based on clinical history, neurologic examination, electrophysiologic studies, CSF studies, and pathologic examination. Early diagnosis and treatment is important to prevent irreversible axonal loss and optimize improvement in function. The first-line agents for treatment are intravenous immunoglobulin (IVIg), corticosteroids, and plasmapheresis, which have all been demonstrated to be effective in controlled studies. Studies have not shown a significant difference between these three treatments, and the initial choice of therapy is often based on availability, cost, ease of administration, and side effect profile. If patients do not respond to one of these agents, they may respond to one of the others and sometimes in combination. If the first-line agents are not effective, chemotherapeutic or immunosuppressive agents may be considered. There are limited controlled studies of these modalities, and they are often used in conjunction with a first-line treatment. The majority of patients require long-term therapy to maintain a response and to prevent relapse.
650		4	\|a Chronic inflammatory demyelinating polyneuropathy (CIDP)
650		4	\|a Intravenous immunoglobulin (IVIg)
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700	1		\|a Brannagan, Thomas H. \|4 aut
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Treatment of Chronic Inflammatory Demyelinating Polyneuropathy

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