Details der Publikation - Arrhythmia Risk Associated with Sleep Disordered Breathing in Chronic Heart Failure

Arrhythmia Risk Associated with Sleep Disordered Breathing in Chronic Heart Failure

Abstract The intersecting relationships of sleep disordered breathing (SDB), arrhythmogenic risk and chronic heart failure (HF) are complex and most likely multi-directional and synergistic. Autonomic dysfunction is a common pathophysiological feature of each of these entities. Intermittent hypoxia, hypercapnia, mechanical cardiac influences due to upper airway obstruction and rostral fluid shifts are SDB-specific mechanisms which may trigger, perpetuate and exacerbate HF and arrhythmogenesis. Specific pathophysiological mechanisms will vary according to the predominance of central as compared to obstructive sleep apnea. The risk of cardiac arrhythmias and HF attributable to SDB may be considerable given the high prevalence of SDB and its likely physiologic burden. The current review focuses on the data, which have accrued elucidating the specific contributory mechanisms of SDB in cardiac arrhythmias and HF, highlighting the clinical relevance and effects of standard SDB treatment on these outcomes, and describing the role of novel therapeutics..

Medienart:	E-Artikel

Erscheinungsjahr:	2013
Erschienen:	2013

Enthalten in:	Zur Gesamtaufnahme - volume:11
Enthalten in:	Current heart failure reports - 11(2013), 1 vom: 15. Nov., Seite 88-97

Sprache:	Englisch

Beteiligte Personen:	Mehra, Reena [VerfasserIn] Redline, Susan [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.85$jKardiologie$jAngiologie
Themen:	Acetazolamide Adaptive servoventilation Apnea hypopnea index Arrhythmia Atrial fibrillation Autonomic dysfunction Cardiac resynchonization therapy Central sleep apnea Cheyne stokes respirations Continuous positive airway pressure Heart failure Hypercapnia Hypoxia Obstructive sleep apnea Oxygen Phrenic nerve stimulation Polysomnography Renal sympathetic denervation Sleep disordered breathing Sudden cardiac death Theophylline Ventricular arrhythmia

Anmerkungen:	© Springer Science+Business Media New York 2013

doi:	10.1007/s11897-013-0171-7

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2102945227

Internformat


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520			\|a Abstract The intersecting relationships of sleep disordered breathing (SDB), arrhythmogenic risk and chronic heart failure (HF) are complex and most likely multi-directional and synergistic. Autonomic dysfunction is a common pathophysiological feature of each of these entities. Intermittent hypoxia, hypercapnia, mechanical cardiac influences due to upper airway obstruction and rostral fluid shifts are SDB-specific mechanisms which may trigger, perpetuate and exacerbate HF and arrhythmogenesis. Specific pathophysiological mechanisms will vary according to the predominance of central as compared to obstructive sleep apnea. The risk of cardiac arrhythmias and HF attributable to SDB may be considerable given the high prevalence of SDB and its likely physiologic burden. The current review focuses on the data, which have accrued elucidating the specific contributory mechanisms of SDB in cardiac arrhythmias and HF, highlighting the clinical relevance and effects of standard SDB treatment on these outcomes, and describing the role of novel therapeutics.
650		4	\|a Acetazolamide
650		4	\|a Adaptive servoventilation
650		4	\|a Apnea hypopnea index
650		4	\|a Arrhythmia
650		4	\|a Atrial fibrillation
650		4	\|a Autonomic dysfunction
650		4	\|a Cardiac resynchonization therapy
650		4	\|a Central sleep apnea
650		4	\|a Cheyne stokes respirations
650		4	\|a Continuous positive airway pressure
650		4	\|a Hypoxia
650		4	\|a Heart failure
650		4	\|a Hypercapnia
650		4	\|a Oxygen
650		4	\|a Obstructive sleep apnea
650		4	\|a Phrenic nerve stimulation
650		4	\|a Polysomnography
650		4	\|a Renal sympathetic denervation
650		4	\|a Sleep disordered breathing
650		4	\|a Sudden cardiac death
650		4	\|a Theophylline
650		4	\|a Ventricular arrhythmia
700	1		\|a Redline, Susan \|4 aut
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Arrhythmia Risk Associated with Sleep Disordered Breathing in Chronic Heart Failure

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