Details der Publikation - Synthesis and anti-acetylcholinesterase activity of benzotriazinone-triazole systems

Synthesis and anti-acetylcholinesterase activity of benzotriazinone-triazole systems

Abstract An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method. Graphical AbstractA series of novel benzotriazinone-triazoles have been synthesized and evaluated as acetylcholinesterase inhibitors..

Medienart:	E-Artikel

Erscheinungsjahr:	2016
Erschienen:	2016

Enthalten in:	Zur Gesamtaufnahme - volume:128
Enthalten in:	Journal of chemical sciences - 128(2016), 9 vom: 30. Aug., Seite 1445-1449

Sprache:	Englisch

Beteiligte Personen:	MOGHIMI, SETAREH [VerfasserIn] GOLI-GARMROODI, FERESHTEH [VerfasserIn] PILALI, HEDIEH [VerfasserIn] MAHDAVI, MOHAMMAD [VerfasserIn] FIROOZPOUR, LOGHMAN [VerfasserIn] NADRI, HAMID [VerfasserIn] MORADI, ALIREZA [VerfasserIn] ASADIPOUR, ALI [VerfasserIn] SHAFIEE, ABBAS [VerfasserIn] FOROUMADI, ALIREZA [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	35.00$jChemie: Allgemeines 35.04$jAusbildung$jBeruf$jOrganisationen$XChemie
Themen:	Acetylcholinesterase Benzotriazinone Diazonium chemistry Nanocatalyst Triazole

Anmerkungen:	© Indian Academy of Sciences 2016

doi:	10.1007/s12039-016-1154-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2102782662

Internformat


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520			\|a Abstract An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method. Graphical AbstractA series of novel benzotriazinone-triazoles have been synthesized and evaluated as acetylcholinesterase inhibitors.
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Synthesis and anti-acetylcholinesterase activity of benzotriazinone-triazole systems

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