Details der Publikation - AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer

AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer

Abstract Astrocyte elevated gene-1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression in various types of human cancers. Here, immunohistochemistry was used to detect AEG-1 expression in nonmuscle-invasive bladder cancer (NMIBC), and these data were examined for correlation with clinicopathological parameters, and prognosis. Immunohistochemical analysis revealed that AEG-1 expression was significantly higher in bladder cancer tissues than that in normal tissues. High expression of AEG-1 was found in 45 % of bladder cancers and significantly associated with tumor grade (P = 0.002) and progression (P = 0.028). The Kaplan–Meier survival analysis demonstrated that AEG-1 expression was significantly associated with shorter progression-free survival (P = 0.0011). Multivariate analysis further demonstrated that AEG-1 was an independent prognostic factor for patients with BC. AEG-1 protein may contribute to the malignant progression of bladder cancer, and present as a novel marker to predict the progression of NMIBC..

Medienart:	E-Artikel

Erscheinungsjahr:	2014
Erschienen:	2014

Enthalten in:	Zur Gesamtaufnahme - volume:31
Enthalten in:	Medical oncology - 31(2014), 6 vom: 15. Mai

Sprache:	Englisch

Beteiligte Personen:	Yang, Guoliang [VerfasserIn] Zhang, Lianhua [VerfasserIn] Lin, Shilong [VerfasserIn] Li, Linfeng [VerfasserIn] Liu, Mengyao [VerfasserIn] Chen, Haige [VerfasserIn] Cao, Ming [VerfasserIn] Liu, Dongming [VerfasserIn] Huang, Yi-ran [VerfasserIn] Bo, Juanjie [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.81$jOnkologie
Themen:	AEG-1 Bladder cancer Prognosis Progression

Anmerkungen:	© Springer Science+Business Media New York 2014

doi:	10.1007/s12032-014-0986-4

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2102620875

Internformat


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520			\|a Abstract Astrocyte elevated gene-1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression in various types of human cancers. Here, immunohistochemistry was used to detect AEG-1 expression in nonmuscle-invasive bladder cancer (NMIBC), and these data were examined for correlation with clinicopathological parameters, and prognosis. Immunohistochemical analysis revealed that AEG-1 expression was significantly higher in bladder cancer tissues than that in normal tissues. High expression of AEG-1 was found in 45 % of bladder cancers and significantly associated with tumor grade (P = 0.002) and progression (P = 0.028). The Kaplan–Meier survival analysis demonstrated that AEG-1 expression was significantly associated with shorter progression-free survival (P = 0.0011). Multivariate analysis further demonstrated that AEG-1 was an independent prognostic factor for patients with BC. AEG-1 protein may contribute to the malignant progression of bladder cancer, and present as a novel marker to predict the progression of NMIBC.
650		4	\|a AEG-1
650		4	\|a Bladder cancer
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700	1		\|a Zhang, Lianhua \|4 aut
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700	1		\|a Huang, Yi-ran \|4 aut
700	1		\|a Bo, Juanjie \|4 aut
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AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer

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