Details der Publikation - Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study

Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study

Abstract This pilot study was undertaken to assess the effect of weekly docetaxel, cisplatin and fluorouracil (DCF) as a preoperative treatment for gastric cancer with multiple synchronous hepatic metastases. Gastric cancer patients with synchronous multiple liver metastasis were first given preoperative chemotherapy consisting of two courses (each course consisted of 6-week administration and 2-week withdrawal) of weekly DCF regimen. Following the operation, postoperative chemotherapy and hepatic arterial infusion (HAI) treatment were performed as required. Eight patients completed two courses of preoperative chemotherapy with weekly DCF regimen. No toxicity of grade 3 or more was observed during the course of chemotherapy. The response rate was 100% according to the RECIST criteria. Seven of the patients have survived for over 1 year, and six of them are still alive after more than 1 year. Because of the unexpected high response to weekly DCF, we consider that it should be verified through phase II and III trials as an important part of the comprehensive treatment for gastric cancer with liver metastasis..

Medienart:	E-Artikel

Erscheinungsjahr:	2009
Erschienen:	2009

Enthalten in:	Zur Gesamtaufnahme - volume:27
Enthalten in:	Medical oncology - 27(2009), 4 vom: 05. Dez., Seite 1314-1318

Sprache:	Englisch

Beteiligte Personen:	Li, Zi-Yu [VerfasserIn] Tang, Lei [VerfasserIn] Zhang, Lian-Hai [VerfasserIn] Bu, Zhao-De [VerfasserIn] Wu, Ai-Wen [VerfasserIn] Wu, Xiao-Jiang [VerfasserIn] Zong, Xiang-Long [VerfasserIn] Wu, Qi [VerfasserIn] Shan, Fei [VerfasserIn] Li, Shuang-Xi [VerfasserIn] Ren, Hui [VerfasserIn] Zhang, Xiao-Peng [VerfasserIn] Ji, Jia-Fu [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.81$jOnkologie
Themen:	Gastric cancer Liver metastasis Preoperative chemotherapy

Anmerkungen:	© Springer Science+Business Media, LLC 2009

doi:	10.1007/s12032-009-9381-y

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2102603431

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520			\|a Abstract This pilot study was undertaken to assess the effect of weekly docetaxel, cisplatin and fluorouracil (DCF) as a preoperative treatment for gastric cancer with multiple synchronous hepatic metastases. Gastric cancer patients with synchronous multiple liver metastasis were first given preoperative chemotherapy consisting of two courses (each course consisted of 6-week administration and 2-week withdrawal) of weekly DCF regimen. Following the operation, postoperative chemotherapy and hepatic arterial infusion (HAI) treatment were performed as required. Eight patients completed two courses of preoperative chemotherapy with weekly DCF regimen. No toxicity of grade 3 or more was observed during the course of chemotherapy. The response rate was 100% according to the RECIST criteria. Seven of the patients have survived for over 1 year, and six of them are still alive after more than 1 year. Because of the unexpected high response to weekly DCF, we consider that it should be verified through phase II and III trials as an important part of the comprehensive treatment for gastric cancer with liver metastasis.
650		4	\|a Preoperative chemotherapy
650		4	\|a Gastric cancer
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700	1		\|a Ren, Hui \|4 aut
700	1		\|a Zhang, Xiao-Peng \|4 aut
700	1		\|a Ji, Jia-Fu \|4 aut
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Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study

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