Innate B Cells: the Archetype of Protective Immune Cells
Abstract The innate B cell (IBC) population is heterogeneous and involved in the primary immune response. IBC functions include a high ability to produce natural antibodies with IgM isotype, the elimination of apoptotic cells, and a capacity to be cognate help to T cells. Among IBC subsets, B-1 cells and marginal zone B cells are the main producers of IgM, act as rapid immune responders that may relocate to follicular lymphoid and differentiate to cytokine and antibody-secreting cells shortly after infection. IBCs functions are highly dependent on their localization site and the nature of their B cell receptor repertoire, suggesting a high plasticity range of different immune responses. In this review, we will describe the nature and functions of the different innate-like B cell subsets, first in mice and then in humans. Besides this, we will emphasize the strong ability of these cells to undertake different protective functions from the first line of defense against pathogens to the regulatory role of the broader immune response..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Clinical reviews in allergy & immunology - 58(2019), 1 vom: 10. Juni, Seite 92-106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Grasseau, Alexis [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Autoreactivity |
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| Anmerkungen: |
© Springer Science+Business Media, LLC, part of Springer Nature 2019 |
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| doi: |
10.1007/s12016-019-08748-7 |
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| funding: |
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| 520 | |a Abstract The innate B cell (IBC) population is heterogeneous and involved in the primary immune response. IBC functions include a high ability to produce natural antibodies with IgM isotype, the elimination of apoptotic cells, and a capacity to be cognate help to T cells. Among IBC subsets, B-1 cells and marginal zone B cells are the main producers of IgM, act as rapid immune responders that may relocate to follicular lymphoid and differentiate to cytokine and antibody-secreting cells shortly after infection. IBCs functions are highly dependent on their localization site and the nature of their B cell receptor repertoire, suggesting a high plasticity range of different immune responses. In this review, we will describe the nature and functions of the different innate-like B cell subsets, first in mice and then in humans. Besides this, we will emphasize the strong ability of these cells to undertake different protective functions from the first line of defense against pathogens to the regulatory role of the broader immune response. | ||
| 650 | 4 | |a Innate B cells | |
| 650 | 4 | |a Effector functions | |
| 650 | 4 | |a IgM | |
| 650 | 4 | |a Autoreactivity | |
| 650 | 4 | |a Regulatory B cells | |
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| 700 | 1 | |a Le Pottier, Laëtitia |4 aut | |
| 700 | 1 | |a Chriti, Nedra |4 aut | |
| 700 | 1 | |a Cornec, Divi |4 aut | |
| 700 | 1 | |a Pers, Jacques-Olivier |4 aut | |
| 700 | 1 | |a Renaudineau, Yves |4 aut | |
| 700 | 1 | |a Hillion, Sophie |4 aut | |
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