Role of $ PM_{2.5} $ in the development and progression of COPD and its mechanisms

Background A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; $ PM_{2.5} $) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted this study to investigate the role of $ PM_{2.5} $ in the development of COPD and associated mechanisms. Methods We firstly conducted a cross-sectional study in Chinese han population to observe $ PM_{2.5} $ effects on COPD morbidity. Then, in vitro, we incubated human bronchial epithelial cells to different concentrations of $ PM_{2.5} $ for 24 h. The expression levels of IL-6 and IL-8 were detected by ELISA and the levels of MMPs, TGF-β1, fibronectin and collagen was determined by immunoblotting. In vivo, we subjected C57BL/6 mice to chronic prolonged exposure to $ PM_{2.5} $ for 48 weeks to study the influence of $ PM_{2.5} $ exposure on lung function, pulmonary structure and inflammation. Results We found that the effect of $ PM_{2.5} $ on COPD morbidity was associated with its levels and that $ PM_{2.5} $ and cigarette smoke could have a synergistic impact on COPD development and progression. Both vitro and vivo studies demonstrated that $ PM_{2.5} $ exposure could induce pulmonary inflammation, decrease lung function, and cause emphysematous changes. Furthermore, $ PM_{2.5} $ could markedly aggravated cigarette smoke-induced changes. Conclusions In short, we found that prolonged chronic exposure to $ PM_{2.5} $ resulted in decreased lung function, emphysematous lesions and airway inflammation. Most importantly, long-term $ PM_{2.5} $ exposure exacerbateed cigarette smoke-induced changes in COPD..

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:20

Enthalten in:

Respiratory research - 20(2019), 1 vom: 13. Juni

Sprache:

Englisch

Beteiligte Personen:

Zhao, Junling [VerfasserIn]
Li, Miao [VerfasserIn]
Wang, Zhihua [VerfasserIn]
Chen, Jinkun [VerfasserIn]
Zhao, Jianping [VerfasserIn]
Xu, Yongjian [VerfasserIn]
Wei, Xiang [VerfasserIn]
Wang, Jianmao [VerfasserIn]
Xie, Jungang [VerfasserIn]

Links:

Volltext [kostenfrei]

Themen:

Airway inflammation
Ambient fine particulate matter
Chronic obstructive pulmonary disease
Emphysematous lesions
Lung function

Anmerkungen:

© The Author(s). 2019

doi:

10.1186/s12931-019-1081-3

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2099889317

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