Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
Background Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and $ FEV_{1} $-decline in male heavy smokers. Methods 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and $ FEV_{1} $-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference. Results Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 – 14.1) and mean (SD) $ FEV_{1} $ was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted ‘>5 years’ showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly $ FEV_{1} $-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001). Conclusion Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline. Trial registration Registered at http://www.trialregister.nl with trial number ISRCTN63545820..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2013 |
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Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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Enthalten in: |
Respiratory research - 14(2013), 1 vom: 20. Mai |
Sprache: |
Englisch |
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Beteiligte Personen: |
Mohamed Hoesein, Firdaus AA [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Themen: |
Chronic obstructive pulmonary disease (COPD) |
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Anmerkungen: |
© Mohamed Hoesein et al.; licensee BioMed Central Ltd. 2013 |
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doi: |
10.1186/1465-9921-14-55 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2099877971 |
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520 | |a Background Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and $ FEV_{1} $-decline in male heavy smokers. Methods 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and $ FEV_{1} $-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference. Results Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 – 14.1) and mean (SD) $ FEV_{1} $ was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted ‘>5 years’ showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly $ FEV_{1} $-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001). Conclusion Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline. Trial registration Registered at http://www.trialregister.nl with trial number ISRCTN63545820. | ||
650 | 4 | |a Chronic obstructive pulmonary disease (COPD) | |
650 | 4 | |a Emphysema | |
650 | 4 | |a Smoking | |
650 | 4 | |a Pulmonary function testing | |
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