Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient
Abstract A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2015 |
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Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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Enthalten in: |
AIDS research and therapy - 12(2015), 1 vom: 21. Mai |
Sprache: |
Englisch |
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Beteiligte Personen: |
Lee, Marcel [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Themen: |
AIDS |
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Anmerkungen: |
© Lee et al.; licensee BioMed Central. 2015 |
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doi: |
10.1186/s12981-015-0054-y |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2099188254 |
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520 | |a Abstract A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments. | ||
650 | 4 | |a HIV | |
650 | 4 | |a AIDS | |
650 | 4 | |a Suicide attempt | |
650 | 4 | |a Dolutegravir | |
650 | 4 | |a Tenofovir disaproxil fumarate | |
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650 | 4 | |a Overdose | |
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700 | 1 | |a Felgenhauer, Norbert |4 aut | |
700 | 1 | |a Klinker, Hartwig HF |4 aut | |
700 | 1 | |a Spinner, Christoph D |4 aut | |
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