Clinically localized type 1 and 2 papillary renal cell carcinomas have similar survival outcomes following surgery

Purpose We aimed to determine incidence, pathologic findings, prognostic factors and clinical outcomes for patients with clinically localized papillary RCC. Methods Demographic, clinical and pathologic findings were collected on all patients with PRCC undergoing surgery at four academic medical centers. The primary endpoint was cancer-specific survival (CSS). Relapse-free survival (RFS) and overall survival (OS) were secondary endpoints. Kaplan–Meier estimates were obtained, and Cox proportional hazard regression models were used to assess predictors of mortality and relapse. Results We identified 626 PRCC, of which 373 (60 %) were type 1 and 253 (40 %) were type 2, with three-quarters of all tumors being pT1. Compared to patients with type 1, those with type 2 were older (mean age: 63 vs 61; p = 0.02), presented more commonly with symptoms (13 vs 7 %; p = 0.02) and had larger mean tumor size (5.2 vs 4.3 cm; p = 0.001). With a median follow-up of 41 months (IQR: 16–68), 92 patients had died of PRCC (15 %), 48 (8 %) experienced relapse, and 101 died from all causes (16 %). The estimated 5-year CSS, RFS and OS were 83, 91 and 82 %, respectively. In multivariable analysis, older age, T stage and nodal status were predictors of CSS and OS. However, PRCC subtype was not a predictor of CSS, RFS or OS. Conclusion While patients with type 2 PRCC appear to present with more advanced disease than patients with type 1, PRCC subtype does not appear to be an independent predictor of CSS, RFS or OS for treated localized disease..

Medienart:

E-Artikel

Erscheinungsjahr:

2015

Erschienen:

2015

Enthalten in:

Zur Gesamtaufnahme - volume:34

Enthalten in:

World journal of urology - 34(2015), 5 vom: 25. Sept., Seite 687-693

Sprache:

Englisch

Beteiligte Personen:

Ledezma, Rodrigo A. [VerfasserIn]
Negron, Edris [VerfasserIn]
Paner, Gladell P. [VerfasserIn]
Rjepaj, Chris [VerfasserIn]
Lascano, Danny [VerfasserIn]
Haseebuddin, Mohammed [VerfasserIn]
Dangle, Pankaj [VerfasserIn]
Shalhav, Arieh L. [VerfasserIn]
Crist, Henry [VerfasserIn]
Raman, Jay D. [VerfasserIn]
Joel DeCastro, G. [VerfasserIn]
Harik, Lara [VerfasserIn]
Paroder, Monika [VerfasserIn]
Uzzo, Robert G. [VerfasserIn]
Kutikov, Alexander [VerfasserIn]
Eggener, Scott E. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Histological type
Papillary RCC
Prognosis
Survival

RVK:

RVK Klassifikation

Anmerkungen:

© Springer-Verlag Berlin Heidelberg 2015

doi:

10.1007/s00345-015-1692-3

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2092633961

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