Secondary acute myeloid leukemia and myelodysplasia after autologous peripheral blood progenitor cell transplantation

Abstract. Secondary myelodysplastic syndrome (MDS) and acute leukemia (AL) are well-known complications of antineoplastic therapy. The incidence of these serious complications after autologous hematopoietic transplantation ranges from 1.1% to 24%. Prior chemotherapy is its most likely cause, but other variables related to these long-term complications are seriously discussed. There is evidence that priming of progenitor cells isolated from peripheral blood with chemotherapy is also related to a higher risk of secondary MDS/AL. Whether progenitor cells isolated from bone marrow or peripheral blood after mobilization only with cytokines are related to higher risk is a controversial issue. In this paper, we analyze the incidence and variables related to these complications in a series of 99 patients diagnosed with lymphoma or multiple myeloma who underwent autologous transplantation using hematopoietic progenitors isolated from peripheral blood mobilized with granulocyte colony-stimulating factor (G-CSF). The probability of MDS/AL in patients alive 5 years after transplant in our series is 8.58%, similar to that reported in other series using bone marrow grafts. The total dose of cyclophosphamide (p=0.099), the number of chemotherapy cycles (p=0.04) received before transplant, and the total dose of mononuclear cells infused at the time of transplant were the only variables associated with secondary MDS/AL. Autologous transplantation with progenitor cells isolated from peripheral blood after mobilization with cytokines has probability and risk factors for secondary MDS/AL development similar to bone marrow grafts when compared with other published series..

Medienart:	E-Artikel

Erscheinungsjahr:	2001
Erschienen:	2001

Enthalten in:	Zur Gesamtaufnahme - volume:81
Enthalten in:	Annals of hematology - 81(2001), 1 vom: 08. Dez., Seite 11-15

Sprache:	Englisch

Beteiligte Personen:	Sevilla, J. [VerfasserIn] Rodríguez, A. [VerfasserIn] Hernández-Maraver, D. [VerfasserIn] de Bustos, J. [VerfasserIn] Aguado, M. [VerfasserIn] Ojeda, E. [VerfasserIn] Arrieta, R. [VerfasserIn] Hernández-Navarro, F. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© Springer-Verlag 2001

doi:	10.1007/s00277-001-0400-0

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PPN (Katalog-ID):	OLC2091668575