Microvascular Transplantation of Adipose Tissue and Serum Level of Adipocyte Products

Abstract Microvascular transplantation of subcutaneous adipose tissue is an essential step in reconstructive surgery after breast carcinoma. Serum levels of adipose tissue products may serve as indicators for transplant function. This study aimed to determine serum leptin and tumor necrosis factor (TNF)-alpha plasma levels pre-, intra-, and postoperatively in 20 patients undergoing reconstructive breast surgery and in 7 women undergoing abdominoplasty operation. In the patients undergoing reconstructive breast surgery, the serum leptin levels decreased intraoperatively from 14.5 ± 13.1 to 9.1 ± 7.3 ng/ml, a decrease of 63%. An increase in serum leptin levels to 13.5 ± 12.7 ng/ml (93% of the initial value) was found on postoperative day 1. This was paralleled by similar changes in the plasma levels of TNF-alpha (preoperatively, 20 ± 7.3 pg/ml; intraoperatively, 17 ± 11.4 pg/ml; postoperatively, 21 ± 10.8 pg/ml). In the patients undergoing abdominoplasty, plasma leptin and TNF-alpha levels decreased intraoperatively (20% and 27%, respectively) and postoperatively (44% and 27%, respectively). The results of our pilot study indicate that a postoperative increase in the level of serum leptin after reconstructive breast surgery may be related to successful transplant function..

Medienart:

E-Artikel

Erscheinungsjahr:

2008

Erschienen:

2008

Enthalten in:

Zur Gesamtaufnahme - volume:32

Enthalten in:

Aesthetic plastic surgery - 32(2008), 3 vom: 08. Apr., Seite 459-463

Sprache:

Englisch

Beteiligte Personen:

Schauer, Herbert [VerfasserIn]
Lechleitner, Monika [VerfasserIn]
Pülzl, Petra [VerfasserIn]
Piza-Katzer, Hildegunde [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.65$jChirurgie

Themen:

Adipose tissue transplantation
Leptin levels

RVK:

RVK Klassifikation

Anmerkungen:

© Springer Science+Business Media, LLC 2008

doi:

10.1007/s00266-007-9015-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2091437212