Details der Publikation - Cerebral small-resistance artery structure and cerebral blood flow in normotensive subjects and hypertensive patients

Cerebral small-resistance artery structure and cerebral blood flow in normotensive subjects and hypertensive patients

Introduction The aim of this study was to prospectively investigate whether the structure of cerebral small-resistance arteries is related to cerebral perfusion parameters as measured with dynamic susceptibility-weighted contrast magnetic resonance imaging (DSC-MRI) in a selected cohort of hypertensive and normotensive patients. Methods Ten hypertensive and 10 normotensive patients were included in the study. All patients underwent neurosurgical intervention for an intracranial tumor and were investigated with DSC-MRI at 1.5 T. Cerebral small-resistance arteries were dissected from a small portion of morphologically normal cerebral tissue and mounted on an isometric myograph for the measurement of the media-to-lumen (M/L) ratio. A quantitative assessment of cerebral blood flow (CBF) and volume (CBV) was performed with a region-of-interest approach. Correlation coefficients were calculated for normally distributed variables. The institutional review board approved the study, and informed consent was obtained from all patients. Results Compared with normotensive subjects, hypertensive patients had significantly lower regional CBF (mL/100 g/min) in the cortical grey matter (55.63 ± 1.90 vs 58.37 ± 2.19, p < 0.05), basal ganglia (53.34 ± 4.39 vs 58.22. ± 4.33, p < 0.05), thalami (50.65 ± 3.23 vs 57.56 ± 4.45, p < 0.01), subcortical white matter (19.32 ± 2.54 vs 22.24 ± 1.9, p < 0.05), greater M/L ratio (0.099 ± 0.013 vs 0.085 ± 0.012, p < 0.05), and lower microvessel density (1.66 ± 0.67 vs 2.52 ± 1.28, p < 0.05). A statistically significant negative correlation was observed between M/L ratio of cerebral arteries and CBF in the cortical grey matter (r = −0.516, p < 0.05), basal ganglia (r = −0.521, p < 0.05), thalami (r = −0.527 p < 0.05), and subcortical white matter (r = −0.612, p < 0.01). Conclusion Our results indicate that microvascular structure might play a role in controlling CBF, with possible clinical consequences..

Medienart:	E-Artikel

Erscheinungsjahr:	2014
Erschienen:	2014

Enthalten in:	Zur Gesamtaufnahme - volume:56
Enthalten in:	Neuroradiology - 56(2014), 12 vom: 10. Sept., Seite 1103-1111

Sprache:	Englisch

Beteiligte Personen:	De Ciuceis, Carolina [VerfasserIn] Cornali, Claudio [VerfasserIn] Porteri, Enzo [VerfasserIn] Mardighian, Dikran [VerfasserIn] Pinardi, Chiara [VerfasserIn] Fontanella, Marco M. [VerfasserIn] Rodella, Luigi F. [VerfasserIn] Rezzani, Rita [VerfasserIn] Rizzoni, Damiano [VerfasserIn] Boari, Gianluca E. M. [VerfasserIn] Rosei, Enrico Agabiti [VerfasserIn] Gasparotti, Roberto [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

BKL:	44.90$jNeurologie 44.64$jRadiologie
Themen:	Cerebral blood flow Cerebral small arteries DSC-MRI Hypertension

RVK:	RVK Klassifikation ELIB24

Anmerkungen:	© Springer-Verlag Berlin Heidelberg 2014

doi:	10.1007/s00234-014-1423-2

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2090753633

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520			\|a Introduction The aim of this study was to prospectively investigate whether the structure of cerebral small-resistance arteries is related to cerebral perfusion parameters as measured with dynamic susceptibility-weighted contrast magnetic resonance imaging (DSC-MRI) in a selected cohort of hypertensive and normotensive patients. Methods Ten hypertensive and 10 normotensive patients were included in the study. All patients underwent neurosurgical intervention for an intracranial tumor and were investigated with DSC-MRI at 1.5 T. Cerebral small-resistance arteries were dissected from a small portion of morphologically normal cerebral tissue and mounted on an isometric myograph for the measurement of the media-to-lumen (M/L) ratio. A quantitative assessment of cerebral blood flow (CBF) and volume (CBV) was performed with a region-of-interest approach. Correlation coefficients were calculated for normally distributed variables. The institutional review board approved the study, and informed consent was obtained from all patients. Results Compared with normotensive subjects, hypertensive patients had significantly lower regional CBF (mL/100 g/min) in the cortical grey matter (55.63 ± 1.90 vs 58.37 ± 2.19, p < 0.05), basal ganglia (53.34 ± 4.39 vs 58.22. ± 4.33, p < 0.05), thalami (50.65 ± 3.23 vs 57.56 ± 4.45, p < 0.01), subcortical white matter (19.32 ± 2.54 vs 22.24 ± 1.9, p < 0.05), greater M/L ratio (0.099 ± 0.013 vs 0.085 ± 0.012, p < 0.05), and lower microvessel density (1.66 ± 0.67 vs 2.52 ± 1.28, p < 0.05). A statistically significant negative correlation was observed between M/L ratio of cerebral arteries and CBF in the cortical grey matter (r = −0.516, p < 0.05), basal ganglia (r = −0.521, p < 0.05), thalami (r = −0.527 p < 0.05), and subcortical white matter (r = −0.612, p < 0.01). Conclusion Our results indicate that microvascular structure might play a role in controlling CBF, with possible clinical consequences.
650		4	\|a Hypertension
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700	1		\|a Fontanella, Marco M. \|4 aut
700	1		\|a Rodella, Luigi F. \|4 aut
700	1		\|a Rezzani, Rita \|4 aut
700	1		\|a Rizzoni, Damiano \|4 aut
700	1		\|a Boari, Gianluca E. M. \|4 aut
700	1		\|a Rosei, Enrico Agabiti \|4 aut
700	1		\|a Gasparotti, Roberto \|4 aut
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Cerebral small-resistance artery structure and cerebral blood flow in normotensive subjects and hypertensive patients

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