The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial
Purpose This study was designed to investigate the effects of omega-3 fatty acids on depression and chronic inflammation in hemodialysis patients. Method Fifty-four maintenance hemodialysis patients were randomized to ingest two omega-3 (each containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid) or placebo capsules, three times daily for 4 months. Main outcome measures: Beck Depression Inventory (BDI) score and serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, ferritin, intact parathyroid hormone (iPTH), and ratios of IL-10 to IL-6 and IL-10 to TNF-α were measured at baseline and at the end of the study. Results Omega-3 supplement lowered BDI score significantly after 4 months of intervention. Among pro- and anti-inflammatory mediators, only serum ferritin level and IL-10 to IL-6 ratio showed significant changes in favor of omega-3 supplement during the study. In linear regression model adjusted for baseline values, omega-3 treatment was a significant predictor of reduced serum CRP, ferritin, and iPTH levels, and increased IL-10 to IL-6 ratio. No significant association was found between the anti-inflammatory and anti-depressant effects of omega-3 supplement. Conclusions Supplemental use of omega-3 fatty acids decreases depressive symptoms in hemodialysis patients apart from their anti-inflammatory effects..
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2014 |
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Erschienen: |
2014 |
Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
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Enthalten in: |
European journal of clinical pharmacology - 70(2014), 6 vom: 20. März, Seite 655-665 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gharekhani, Afshin [VerfasserIn] |
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Links: |
Volltext [lizenzpflichtig] |
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Themen: |
Anti-inflammatory |
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RVK: |
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Anmerkungen: |
© Springer-Verlag Berlin Heidelberg 2014 |
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doi: |
10.1007/s00228-014-1666-1 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
OLC2090647507 |
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245 | 1 | 0 | |a The effect of omega-3 fatty acids on depressive symptoms and inflammatory markers in maintenance hemodialysis patients: a randomized, placebo-controlled clinical trial |
264 | 1 | |c 2014 | |
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520 | |a Purpose This study was designed to investigate the effects of omega-3 fatty acids on depression and chronic inflammation in hemodialysis patients. Method Fifty-four maintenance hemodialysis patients were randomized to ingest two omega-3 (each containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid) or placebo capsules, three times daily for 4 months. Main outcome measures: Beck Depression Inventory (BDI) score and serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, ferritin, intact parathyroid hormone (iPTH), and ratios of IL-10 to IL-6 and IL-10 to TNF-α were measured at baseline and at the end of the study. Results Omega-3 supplement lowered BDI score significantly after 4 months of intervention. Among pro- and anti-inflammatory mediators, only serum ferritin level and IL-10 to IL-6 ratio showed significant changes in favor of omega-3 supplement during the study. In linear regression model adjusted for baseline values, omega-3 treatment was a significant predictor of reduced serum CRP, ferritin, and iPTH levels, and increased IL-10 to IL-6 ratio. No significant association was found between the anti-inflammatory and anti-depressant effects of omega-3 supplement. Conclusions Supplemental use of omega-3 fatty acids decreases depressive symptoms in hemodialysis patients apart from their anti-inflammatory effects. | ||
650 | 4 | |a Anti-inflammatory | |
650 | 4 | |a Depression | |
650 | 4 | |a Fish oil | |
650 | 4 | |a Hemodialysis | |
650 | 4 | |a Inflammation | |
650 | 4 | |a Omega-3 fatty acids | |
700 | 1 | |a Khatami, Mohammad-Reza |4 aut | |
700 | 1 | |a Dashti-Khavidaki, Simin |4 aut | |
700 | 1 | |a Razeghi, Effat |4 aut | |
700 | 1 | |a Noorbala, Ahmad-Ali |4 aut | |
700 | 1 | |a Hashemi-Nazari, Seyed-Saeed |4 aut | |
700 | 1 | |a Mansournia, Mohammad-Ali |4 aut | |
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