Incentive salience of cocaine across the postpartum period of the female rat

Rationale–Objectives Our prior conditioned place preference (CPP) work demonstrates that late (day16) postpartum female rats consistently prefer cocaine- over pup-associated chambers, whereas far fewer early postpartum (day8) females prefer the cocaine-associated chamber. The present study examines early and late postpartum females’ preference for a cocaine-associated chamber when contrasted with a chamber associated with saline (rather than pups). Materials and methods Postpartum females were tested for conditioned preference for chambers associated with cocaine (10 mg/kg subcutaneous (SC) or 0.5, 5, 10, or 20 mg/kg intraperitoneal (IP) injections) versus saline; preferences of virgin female and male rats for select cocaine stimuli (10mg/kg SC or IP) were also tested. Locomotion was recorded during CPP conditioning and testing. Results Early and late postpartum females expressed strikingly similar preference for the cocaine-associated chamber across all administration routes and doses. IP cocaine produced an orderly, inverted U-shaped dose-preference curve, with preference peaking at the 5 mg/kg dose (83% of females). While many postpartum females preferred 10mg/kg cocaine administered either SC or IP, both virgin females and males expressed strong aversion to SC cocaine and, while virgin females strongly preferred IP cocaine, males remained relatively indifferent. Across 10mg/kg IP cocaine-conditioning sessions, locomotor sensitization occurred exclusively in cocaine- but not saline-preferring postpartum females. Locomotor rate was lower in preferred versus nonpreferred chambers at CPP test. Conclusions Early and late postpartum females may be equally and uniquely susceptible to sampling and/or abuse of modestly salient doses of cocaine (10mg/kg SC; 5mg/kg IP) compared to virgin females and/or males..

Medienart:

E-Artikel

Erscheinungsjahr:

2008

Erschienen:

2008

Enthalten in:

Zur Gesamtaufnahme - volume:199

Enthalten in:

Psychopharmacology - 199(2008), 1 vom: 11. Mai, Seite 119-130

Sprache:

Englisch

Beteiligte Personen:

Seip, Katharine M. [VerfasserIn]
Pereira, Mariana [VerfasserIn]
Wansaw, Michael P. [VerfasserIn]
Reiss, Jenny I. [VerfasserIn]
Dziopa, Eugenia I. [VerfasserIn]
Morrell, Joan I. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Cocaine
Conditioning
Female
Lactation
Locomotor activity
Male
Motivation
Place preference
Rat
Sex differences

RVK:

RVK Klassifikation

Anmerkungen:

© Springer-Verlag 2008

doi:

10.1007/s00213-008-1140-9

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2087479933

Zugang & Verfügbarkeit




Zugehörige Publikationen/Bände

    Haven't found what you're looking for?