Intraobserver and interobserver variability in the calculation of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) of breast tumours

Purpose This study evaluated intraobserver and interobserver variability in the measurement of apparent diffusion coefficient (ADC) values in breast carcinomas. Materials and methods Twenty-eight patients with solid breast lesions >10 mm underwent conventional contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted MRI (DW-MRI). Two observers (expert and trainee) segmented the lesion from the surrounding breast tissue on DW images with high b-value (1,000 s/$ mm^{2} $). This analysis was repeated by the expert reader after 6 months. Volumes were analysed to obtain mean, median and standard deviation (SD) of the ADC values. Interobserver and intraobserver variation was analysed using the Bland-Altman graph. Results All lesions were breast carcinomas, with a mean ADC value of 1.07 × $ 10^{−3} $ $ mm^{2} $/s. The mean of the differences was 0.012 × $ 10^{−3} $ $ mm^{2} $/s, corresponding to an intraobserver variability of 1.1% (limits of agreement: −5%/+8%). The mean interobserver difference was 0.022 × $ 10^{−3} $ $ mm^{2} $/s, corresponding to an interobserver variability of 2% (limits of agreement: −9%/+14%). Conclusions We found a low intraobserver and interobserver variability in calculating ADC in breast carcinomas, which supports its potential use in routine clinical practice..

Medienart:

E-Artikel

Erscheinungsjahr:

2011

Erschienen:

2011

Enthalten in:

Zur Gesamtaufnahme - volume:116

Enthalten in:

La Radiologia medica - 116(2011), 3 vom: 12. Jan., Seite 466-476

Sprache:

Englisch

Beteiligte Personen:

Petralia, G. [VerfasserIn]
Bonello, L. [VerfasserIn]
Summers, P. [VerfasserIn]
Preda, L. [VerfasserIn]
Malasevschi, A. [VerfasserIn]
Raimondi, S. [VerfasserIn]
Di Filippi, R. [VerfasserIn]
Locatelli, M. [VerfasserIn]
Curigliano, G. [VerfasserIn]
Renne, G. [VerfasserIn]
Bellomi, M. [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

Themen:

Breast carcinoma
Diffusion-weighted magnetic resonance imaging
Interobserver variability
Intraobserver variability

Anmerkungen:

© Springer-Verlag Italia 2011

doi:

10.1007/s11547-011-0616-z

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2087198268

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